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Genomicsba3dbe29-0fd7-4ee5-99b8-d69d3c381e6e - samples
The BAM files for WES and RNA seq used in the article "Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases." on cancer Discovery 2019. PMID: 30787016 PMCID: PMC6497554. Authors : Grant M Fischer, ..., Michael A Davies.
EGAD00001005046 | EGA
TranscriptomicsMicrocolony formation by the opportunistic pathogen Pseudomonas aeruginosa requires pyruvate and pyruvate fermentation.
A hallmark of the biofilm architecture is the presence of microcolonies. However, little is known about the underlying mechanisms governing microcolony formation. In the human pathogen Pseudomonas aeruginosa, microcolony formation is dependent on the two-component regulator MifR, with mifR mutant bi...
ORGANISM(S): Pseudomonas aeruginosa 
2012-04-30 | E-GEOD-35286 | biostudies-arrayexpress
ProteomicsHypoxia promotes the generation of a versican-rich extracellular matrix by human coronary artery endothelial cells
• Exposure of endothelial cells (HCAECs) to hypoxia alters gene an protein expression • Genes and proteins related to endothelial dysfunction and activation are overexpressed • Hypoxia induces a versican-rich matrix with an altered glycosaminoglycan profile • This modified matrix perturbs cell adhes...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD052078 | Pride
Ecm Hypoxia Proteomics 
TranscriptomicsPseudomonas aeruginosa two-component regulator BfmR controls bacteriophage lysis and DNA release during biofilm development through PhdA
Biofilms are surface-adhered bacterial communities encased in an extracellular matrix composed of polysaccharides, proteins, and extracelluar (e)DNA, with eDNA being required for the formation and integrity of biofilms. Here we demonstrate that the spatial and temporal release of eDNA is regulated b...
ORGANISM(S): Pseudomonas aeruginosa 
2011-06-01 | E-GEOD-28953 | biostudies-arrayexpress
UnknownSynthesis and cellular evaluation of click-chemistry probes to study the biological effects of alpha, beta-unsaturated carbonyls.
Not available
S-EPMC8966197 | biostudies-literature
ProteomicsSpatial proteomics of the human atherosclerotic microenvironment reveals heterogeneity in intra-plaque proteomes and extracellular matrix remodeling
The heterogeneity of atherosclerotic plaques is critical for their vulnerability to rupture and the associate risk of cardiovascular events. Most proteomic studies have only examined bulk changes, potentially obscuring key spatial differences in protein content and abundance. Here we report a high-r...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-08-13 | PXD072200 | Pride
Human Atherosclerosis Spatial proteomics Myocardium Mouse Lcm L md 
ProteomicsHeparan sulfate Sulfatases are essential for the patterning of human stem cell-derived midbrain dopaminergic neurons
Midbrain dopaminergic neurons (mDA) are selectively lost in Parkinson’s disease (PD), driving sustained efforts to generate bona fide mDA neurons from human-induced pluripotent stem cells (iPSCs) for replacement therapy. While morphogen gradients and transcription factors have been extensively studi...
ORGANISM(S): Homo sapiens (Human) 
2026-07-16 | PXD075443 | Pride
Human Ipsc 
TranscriptomicsCpG island methylation
We compare the methylation status of CpG island clones by MeDIP in SW48 colon cancer cells relative to normal colon mucosa and WI38 primary fibroblasts.
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-2653 | biostudies-arrayexpress
TranscriptomicsEpigenomic profiles
Chromosomal methylation profiles of normal and transformed cell lines
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-2664 | biostudies-arrayexpress
UnknownThe crystal structure of SUN1-KASH6 reveals an asymmetric LINC complex architecture compatible with nuclear membrane insertion.
Not available
S-EPMC10827754 | biostudies-literature
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