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GenomicsThree distinct patterns of histone H3Y41 phosphorylation mark active genes
The aim of the project was to identify the global distribution of H3Y41ph and correlate its presence with the transcription factor STAT5 and the active histone modification H3K4me3. This was done in human erythroid leukaemia cells (HEL). HEL cells were treated with DMSO or a JAK2 inhibitor (TG101209...
ORGANISM(S): Homo sapiens 
2013-04-15 | E-MTAB-1096 | biostudies-arrayexpress
TranscriptomicsTranscriptomic assessment of resistance to effects of an aryl hydrocarbon receptor (AHR) agonist in embryos of Atlantic killifish (Fundulus heteroclitus) from a marine Superfund site
This study presents statistical analyses of gene expression in 5, 10 and 15 day post-fertilization (dpf) embryos of the teleost Fundulus heteroclitus treated with control vehicle (DMSO) or a potent non-ortho-PCB (PCB-126; 3,3’,4,4’,5-pentachlorobiphenyl). The embryos were from two populations: a cl...
ORGANISM(S): Fundulus heteroclitus 
2011-06-06 | E-GEOD-25245 | biostudies-arrayexpress
GenomicsDriver mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in Acute Myeloid Leukemia
Recent evidence suggests that inhibition of BET epigenetic readers may have clinical utility in hematological malignancies. We demonstrate the efficacy of the BET inhibitor I-BET151 across a variety of AML subtypes, and demonstrate that a common core transcriptional program, which is HOX gene-indepe...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-MTAB-1443 | biostudies-arrayexpress
ProteomicsCandida albicans (DAY286 biofilm) extracellular vesicle and whole cell lysate proteomes
We performed proteomic analysis of extracellular vesicles (EVs) and whole cell lysates (WCL) isolated from the same biofilm (strain = DAY286, n = 5). We identified proteins enriched in EVs versus WCL by comparing their LFQ intensities across all samples. After linking these results with EV enrichmen...
ORGANISM(S): Candida albicans (Yeast) 
2020-04-17 | PXD014389 | Pride
Ev Candida Qexactive Biofilm Lc-ms/ms 
ProteomicsCandida albicans (DAY286 yeast) extracellular vesicle and whole cell lysate proteomes
We performed proteomic analysis of extracellular vesicles (EVs) and whole cell lysates (WCL) isolated from the same liquid culture (strain = DAY286, n = 3). This data set is the first label-free quantitative comparative study of the proteins in C. albicans EVs and their parent planktonic (yeast-form...
ORGANISM(S): Candida albicans (Yeast) 
2020-04-17 | PXD014367 | Pride
Ev Candida Qexactive Lc-ms/ms 
ProteomicsCandida albicans (ATCC90028 and ATCC10231 yeast) extracellular vesicle and whole cell lysate proteomes
We performed proteomic analysis of extracellular vesicles (EVs) and whole cell lysates (WCL) isolated from the same liquid culture. This was implemented for two different C. albicans strains, ATCC90028 (n = 3) and ATCC10231 (n = 3). This data set is the first label-free quantitative comparative stud...
ORGANISM(S): Candida albicans (Yeast) 
2020-04-17 | PXD014388 | Pride
Ev Candida Qexactive Lc-ms/ms 
GenomicsChIP of BET proteins in iBET resistance [ChIP-seq]
Bromodomain and Extra Terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a new therapeutic paradigm by directly targeting epigenetic readers1,2. Early clinical trials have shown significant promise especially in acute myeloid leukaemia (AML)3; therefore the evaluati...
ORGANISM(S): Mus musculus 
2015-09-15 | E-GEOD-63682 | biostudies-arrayexpress
TranscriptomicsGenome wide expression analysis of BET inhibitor resistance [RNA-seq]
Bromodomain and Extra Terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a new therapeutic paradigm by directly targeting epigenetic readers1,2. Early clinical trials have shown significant promise especially in acute myeloid leukaemia (AML)3; therefore the evaluati...
ORGANISM(S): Mus musculus 
2015-09-15 | E-GEOD-63681 | biostudies-arrayexpress
TranscriptomicsGenome wide expression analysis of BET inhibitor resistance
Bromodomain and Extra Terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a new therapeutic paradigm by directly targeting epigenetic readers. Early clinical trials have shown significant promise especially in acute myeloid leukaemia (AML)3; therefore the evaluation ...
ORGANISM(S): Mus musculus 
2015-09-15 | E-GEOD-63575 | biostudies-arrayexpress
GenomicsGenome-wide analysis of the binding pattern of the transcriptional co-activator Cbp.
The transcriptional coactivator Cbp is critical for hematopoietic stem cell (HSC) development. However, its role in adult HSC and the mechanistic detail of Cbp control of HSC function remain unknown. Using conditional deletion of Cbp in the adult HSC compartment, we demonstrate an altered balance be...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-25265 | biostudies-arrayexpress
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