Sort   by:  
 Page size 
GenomicsThree distinct patterns of histone H3Y41 phosphorylation mark active genes
The aim of the project was to identify the global distribution of H3Y41ph and correlate its presence with the transcription factor STAT5 and the active histone modification H3K4me3. This was done in human erythroid leukaemia cells (HEL). HEL cells were treated with DMSO or a JAK2 inhibitor (TG101209...
ORGANISM(S): Homo sapiens 
2013-04-15 | E-MTAB-1096 | biostudies-arrayexpress
UnknownSWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma.
Not available
S-EPMC4534524 | biostudies-literature
TranscriptomicsInhibition of bromodomain and extra-terminal (BET) recruitment to chromatin as an effective treatment for mixed lineage leukaemia (MLL)-fusion leukaemia
Gene expression changes in MLL leukaemia following I-BET151 treatment. Note: Additional archives available (E-MTAB-774.additional.1.zip and E-MTAB-774.additional.2.zip) containing individual raw files. Select 'Browse all available files' to view.
ORGANISM(S): Homo sapiens 
2011-09-30 | E-MTAB-774 | biostudies-arrayexpress
TranscriptomicsJarid2 regulates hematopoietic stem cell function by acting with Polycomb Repressive Complex 2
Polycomb Repressive Complex 2 (PRC2) has been shown to play a key role in hematopoietic stem and progenitor cell (HSPC) function. Analyses of mouse mutants harboring deletions of core components have implicated PRC2 in fine-tuning multiple pathways that instruct HSPC behavior, yet how PRC2 is target...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-60808 | biostudies-arrayexpress
ProteomicsCandida albicans (DAY286 yeast) extracellular vesicle and whole cell lysate proteomes
We performed proteomic analysis of extracellular vesicles (EVs) and whole cell lysates (WCL) isolated from the same liquid culture (strain = DAY286, n = 3). This data set is the first label-free quantitative comparative study of the proteins in C. albicans EVs and their parent planktonic (yeast-form...
ORGANISM(S): Candida albicans (Yeast) 
2020-04-17 | PXD014367 | Pride
Ev Candida Qexactive Lc-ms/ms 
ProteomicsCandida albicans (DAY286 biofilm) extracellular vesicle and whole cell lysate proteomes
We performed proteomic analysis of extracellular vesicles (EVs) and whole cell lysates (WCL) isolated from the same biofilm (strain = DAY286, n = 5). We identified proteins enriched in EVs versus WCL by comparing their LFQ intensities across all samples. After linking these results with EV enrichmen...
ORGANISM(S): Candida albicans (Yeast) 
2020-04-17 | PXD014389 | Pride
Ev Candida Qexactive Biofilm Lc-ms/ms 
ProteomicsCandida albicans (ATCC90028 and ATCC10231 yeast) extracellular vesicle and whole cell lysate proteomes
We performed proteomic analysis of extracellular vesicles (EVs) and whole cell lysates (WCL) isolated from the same liquid culture. This was implemented for two different C. albicans strains, ATCC90028 (n = 3) and ATCC10231 (n = 3). This data set is the first label-free quantitative comparative stud...
ORGANISM(S): Candida albicans (Yeast) 
2020-04-17 | PXD014388 | Pride
Ev Candida Qexactive Lc-ms/ms 
GenomicsDriver mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in Acute Myeloid Leukemia
Recent evidence suggests that inhibition of BET epigenetic readers may have clinical utility in hematological malignancies. We demonstrate the efficacy of the BET inhibitor I-BET151 across a variety of AML subtypes, and demonstrate that a common core transcriptional program, which is HOX gene-indepe...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-MTAB-1443 | biostudies-arrayexpress
TranscriptomicsSingle cell RNAseq of haploidized HCT116 colorectal carcinoma cells expressing specific p53 mutations treated with either DMSO or Nutlin
Colorectal carcinoma cell line HCT116 cells were used as a model system to investigate the heterogeneity of different TP53 mutations. To this end, cells were haploidized by deleting an intronic splice site in one of the two wild-type TP53 alleles while the other copy was altered to different loss-of...
ORGANISM(S): Homo sapiens 
2024-10-16 | E-MTAB-13904 | biostudies-arrayexpress
UnknownPancreatic cancer patient survival correlates with DNA methylation of pancreas development genes.
Not available
S-EPMC4454596 | biostudies-literature
Sort   by:  
 Page size