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UnknownEffectiveness of the Ad26.COV2.S vaccine in health-care workers in South Africa (the Sisonke study): results from a single-arm, open-label, phase 3B, implementation study.
Not available
S-EPMC8930006 | biostudies-literature
ProteomicsDiscovery, target identification and lead optimisation of a quinazoline series with potent anti-Chagasic activity
We next used an approach to determine the direct binding of quinazolines to their target(s). A protein can be stabilised or destabilised through the binding of a ligand, altering that proteins thermostability. Such alterations in thermostability can cause a ligated protein to denature at a different...
ORGANISM(S): Trypanosoma cruzi Dm28c 
2025-04-22 | PXD050235 | Pride
Drug target Trypanosoma cruzi Thermal proteome profiling 
TranscriptomicsGenome-wide localization of Ino80 and Arp5 on chromosome in Saccharomyces cerevisiae
Background: Chromatin remodeling complexes facilitate the access of enzymes that mediate transcription, replication or repair of DNA by modulating nucleosome position and/or composition. Ino80 is the DNA-dependent Snf2-like ATPase subunit of a complex whose nucleosome remodeling activity requires ac...
ORGANISM(S): Saccharomyces cerevisiae 
2008-04-10 | E-GEOD-9233 | biostudies-arrayexpress
UnknownPharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death.
Not available
S-EPMC9390741 | biostudies-literature
ProteomicsTarget deconvolution in Plasmodium falciparum using pulldowns
Parasite lysates were centrifuged (20,000 g, 4°C, 15 min). Beads (blank and with linker attached) were washed 3× with water then twice with lysis buffer. The lysate (~2 mg total protein) was first incubated with 2 mg blank beads for 30 min at 4°C with rotating agitation. The lysate was divided into ...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-10-15 | PXD033740 | Pride
Pulldown Plasmodium falciparum Drug target Chemical proteomics 
TranscriptomicsTranscription profiling of human peripheral blood lymphocytes: comparison between melanoma patients and healthy controls
We focused on the major peripheral blood lymphocyte populations that may be involved in anti-tumor responses and negatively impacted by cancer, specifically CD8 T cells, CD4 T cells, B cells and CD56dim natural killer cells. The pure cell subsets were stringently sorted by flow cytometry from PBMC s...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6887 | biostudies-arrayexpress
TranscriptomicsIL-33 activates tumor stroma to promote intestinal polyposis
Tumor epithelial cells develop within a microenvironment consisting of extracellular matrix, growth factors, and cytokines produced by non-epithelial stromal cells. In response to paracrine signals from tumor epithelia, stromal cells modify the microenvironment to promote tumor growth and metastasis...
ORGANISM(S): Homo sapiens 
2015-04-29 | E-GEOD-62518 | biostudies-arrayexpress
ProteomicsDrug target deconvolution in Plasmodium falciparum using thermal proteomics profiling
Early identification of a compound’s mode of action can greatly benefit the discovery process. Thermal proteomics profiling (TPP) is a powerful, unbiased tool that can be used to identify potential ligands of protein targets. TPP takes advantage of the fact that a ligand binding to its target prot...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-10-13 | PXD025182 | Pride
Lysine trna synthetase Thermal proteome profiling Plasmodium falciparum 
TranscriptomicsC. elegans embryos: control vs. mes-2 mutant
Transcriptional profiling of early C. elegans embryos comparing control (N2) embryos with mes-2 mutant embryos at different developmental stages: 2E (24-40 cells), 4E (50-90 cells) and 8E stage (100-200 cells). Goal was to determine the effects of mes-2 loss on global gene expression as embryos tran...
ORGANISM(S): Caenorhabditis elegans 
2010-05-18 | E-GEOD-14913 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human biopsies of Nasopharyngeal carcinoma (NPC) and non-malignant controls
Nasopharyngeal carcinoma (NPC) is a common cancer in southern China and South East Asia where more than 50,000 new cases are diagnosed each year. We used microarrays to identify down or upregulated genes in NPC compared with non-malignant controls. Experiment Overall Design: Snap frozen nasopharynge...
ORGANISM(S): Homo sapiens 
2009-11-10 | E-GEOD-13597 | biostudies-arrayexpress
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