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MetabolomicsMulti-omics phenotyping of the gut-liver axis reveals metabolic perturbations from a low-dose pesticide mixture in rats
Health effects of pesticides are not always accurately detected using the current battery of regulatory toxicity tests. We compared standard histopathology and serum biochemistry measures and multi-omics analyses in a subchronic toxicity test of a mixture of six pesticides frequently detected in foo...
2020-11-19 | MTBLS138 | MetaboLights
TranscriptomicsTranscription profiling of eyes from wild type and Bma knock-out mice after different lengths of time in a 12:12-hr LD cycle or in constant darkness to identify daily rhythms in ocular gene expression
To explore daily rhythms of ocular gene expression in adult mice we performed the following experiments: i) Mice were entrained to a 12:12-hr light-dark (LD) cycle for 3 weeks. Then mice were transferred to constant darkness (DD) or remained in LD and eyes were collected at four-hour intervals over ...
ORGANISM(S): Mus musculus 
2007-08-24 | E-TABM-285 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse day 0 versus day 1 involuting mammary gland
Mammary gland involution represents one of the most dramatic examples of programmed cell death/apoptosis and tissue regression during development, yet large gaps still exist in the understanding of the mechanisms involved, and the key factors that trigger involution, are not yet identified. With the...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5317 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Hepatitis C patients - responders and non-responders to antiviral therapies peg interferon and ribavirin against hepatitis C
Time series of gene expression arrays before and during treatment of Hepatitis C; days 0, 1, 2, 7, 14 and 28 for 69 participants (IDs 1 through 69 are used). Treating chronic hepatitis C using peginterferon alpha and ribavirin leads to sustained clearance of virus and clinical improvement in approxi...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-7123 | biostudies-arrayexpress
TranscriptomicsInfluence of short-time feeding of rats with an iron-deficient diet on their hepatic gene expression profiles
Iron deficiency-induced anemia is generally a representative nutritional problem in most populations. We reported that the anemia due to dietary iron deficiency causes a variety of changes in nutrient metabolism, even leading to apoptosis as a result of associated endoplasmic reticulum (ER) stress i...
ORGANISM(S): Rattus norvegicus 
2013-03-21 | E-GEOD-30533 | biostudies-arrayexpress
TranscriptomicsSub-chronic forestomach transcriptional response in adult male MutaTMMouse following oral exposure to benzo(a)pyrene
Benzo(a)pyrene is a well-established human carcinogen in humans and rodents. In the present study, we sought to determine the dose- and time-dependent changes in gene expression upon oral exposure to benzo(a)pyrene. Adult male MutaTMMouse were exposed to three doses of benzo(a)pyrene or vehicle cont...
ORGANISM(S): Mus musculus 
2013-09-27 | E-GEOD-43438 | biostudies-arrayexpress
UnknownStability Characterization of the Novel Anti-Cancer HM-10/10 HDL-Mimetic Peptide.
Not available
S-EPMC10298982 | biostudies-literature
UnknownPhysiology of spontaneous [Ca(2+)]i oscillations in the isolated vasopressin and oxytocin neurones of the rat supraoptic nucleus.
Not available
S-EPMC4969632 | biostudies-literature
TranscriptomicsTranscription profiling of mouse brain from animals treated with cocaine vs controls
Several recent reports show that the cerebral cortex in humans and animals with altered expressions of Wnt/cadherin network-associate molecules display cytoarchitectural abnormalities reminiscent of cortical dysplasias seen in some (mouse-, rat-, and monkey-based) animal models of prenatal cocaine e...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6628 | biostudies-arrayexpress
TranscriptomicsTranscription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling
We used transcriptional profiling to monitor gene expression of whole olfactory bulbs at daily intervals from embryonic day 11 through birth, generating a compendium of gene expression encompassing the major developmental events of this tissue. OBs from CD1 mice (Charles River Laboratories, Wilmingt...
ORGANISM(S): Mus musculus 
2011-01-04 | E-GEOD-26406 | biostudies-arrayexpress
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