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Proteomics(Phospho)-proteomic characterization of longitudinal biopsies from HCC patients treated with sorafenib
Tumor response rates to targeted therapy are generally low. This poses an urgent medical need to identify molecular mechanisms that determine responsiveness, to inform drug development and therapy. Here, we performed a proteomics and phospho-proteomics (p)proteomics analysis on longitudinal tumor bi...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD028593 | Pride
Human Super-silac Sorafenib (phospho)-proteomics ((p)proteomics) Hepatocellular carcinoma (hcc) Biopsies 
ProteomicsPhospho-proteomic characterization of human hepatocellular carcinoma (HCC) tumor biopsies
We analyzed the phospho-proteome of tumor and matched non-tumor biopsies from 51 treatment-naive Hepatocellular carcinoma (HCC) patients by label-free DDA. Thereby we aim to find subgroups of patients characterized by specific pathway activation. Furthermore, we aim to find novel factors involved in...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD025836 | Pride
Human Qexactive hf Phospho-proteomics Hepatocellular carcinoma (hcc) Biopsies 
ProteomicsProteomic characterization of human hepatocellular carcinoma (HCC) tumor biopsies
We analyzed the proteome of tumor and matched non-tumor biopsies from 51 treatment-naive Hepatocellular carcinoma (HCC) patients by DIA (SWATH). Thereby we aim to find subgroups of patients characterized by specific pathway activation. Furthermore, we aim to find novel factors involved in HCC develo...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD025705 | Pride
Human Swath Biopsies Hcc 
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