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TranscriptomicsDCC binding and function (ChIP-chip: DPY-27)
In many species, a dosage compensation complex (DCC) is targeted to X chromosomes of one sex to equalize levels of X gene products between males (1X) and females (2X). Here we identify cis-acting regulatory elements that target the C. elegans X chromosome for repression by the DCC. The DCC binds t...
ORGANISM(S): Caenorhabditis elegans 
2010-05-22 | E-GEOD-14651 | biostudies-arrayexpress
TranscriptomicsDCC binding and function (ChIP-chip: SDC-2)
In many species, a dosage compensation complex (DCC) is targeted to X chromosomes of one sex to equalize levels of X gene products between males (1X) and females (2X). Here we identify cis-acting regulatory elements that target the C. elegans X chromosome for repression by the DCC. The DCC binds t...
ORGANISM(S): Caenorhabditis elegans 
2010-05-22 | E-GEOD-14652 | biostudies-arrayexpress
TranscriptomicsDCC binding and function (ChIP-chip: SDC-3, DPY-27, Mock)
In many species, a dosage compensation complex (DCC) is targeted to X chromosomes of one sex to equalize levels of X gene products between males (1X) and females (2X). Here we identify cis-acting regulatory elements that target the C. elegans X chromosome for repression by the DCC. The DCC binds t...
ORGANISM(S): Caenorhabditis elegans 
2010-05-22 | E-GEOD-14653 | biostudies-arrayexpress
TranscriptomicsDCC binding and function (ChIP-chip: SDC-3, MIX-1, DPY-27, Mock)
In many species, a dosage compensation complex (DCC) is targeted to X chromosomes of one sex to equalize levels of X gene products between males (1X) and females (2X). Here we identify cis-acting regulatory elements that target the C. elegans X chromosome for repression by the DCC. The DCC binds t...
ORGANISM(S): Caenorhabditis elegans 
2010-05-22 | E-GEOD-14650 | biostudies-arrayexpress
ProteomicsLC-MSMS of DCC and Neuropilin-1 immunoprecipitated samples from Xenopus Laevis brains
During neuronal wiring, extrinsic cues trigger the local translation of specific mRNAs in axons via cell surface receptors. The coupling of ribosomes to receptors has been proposed as a mechanism linking signals to local translation but it is not known how broadly this mechanism operates, nor whethe...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2019-12-02 | PXD015650 | Pride
Lc-msms Neuropilin-1 Dcc Xenopus laevis brains Lfq Immunoprecipitation 
TranscriptomicsExamination of DPY-30, DPY-27, SDC-3, DPY-26, MIX-1, SMC-4, ASH-2, RNA Polymerase II binding in wild type and DCC mutant embryos
Here we exploit the essential process of X-chromosome dosage compensation to elucidate basic mechanisms that control the assembly, genome-wide binding, and function of gene regulatory complexes that act over large chromosomal territories. We demonstrate that a subunit of C. elegans MLL/COMPASS, a g...
ORGANISM(S): Caenorhabditis elegans 
2011-03-01 | E-GEOD-25833 | biostudies-arrayexpress
TranscriptomicsA condensin-like dosage compensation complex acts at a distance to control expression throughout the genome
This SuperSeries is composed of the following subset Series: GSE14649: DCC binding and function (Expression Analysis) GSE14650: DCC binding and function (ChIP-chip: SDC-3, MIX-1, DPY-27, Mock) GSE14651: DCC binding and function (ChIP-chip: DPY-27) GSE14652: DCC binding and function (ChIP-chip: SDC-2...
ORGANISM(S): Caenorhabditis elegans 
2010-05-22 | E-GEOD-14640 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C. elegans to investigate dosage compensation complex (DCC) binding and function
In many species, a dosage compensation complex (DCC) is targeted to X chromosomes of one sex to equalize levels of X gene products between males (1X) and females (2X). Here we identify cis-acting regulatory elements that target the C. elegans X chromosome for repression by the DCC. The DCC binds t...
ORGANISM(S): Caenorhabditis elegans 
2009-03-07 | E-GEOD-14649 | biostudies-arrayexpress
TranscriptomicsAnalysis of SDC-2, DPY-26, MIX-1, DPY-27 and RNA Polymerase II ChIP-chip and RNA abundance in C. elegans
In C. elegans, a condensin-like protein complex associates specifically with both X chromosomes of XX animals to execute dosage compensation. Dosage Compensation Complex (DCC) reduces the level of transcripts arising from each of the two X chromosomes. Recruitment to X is specified in part by discre...
ORGANISM(S): Caenorhabditis elegans 
2009-11-15 | E-GEOD-16621 | biostudies-arrayexpress
TranscriptomicsComparison of DPY-27 binding in embryos and fed L1 larvae
Here we exploit the essential process of X-chromosome dosage compensation to elucidate basic mechanisms that control the assembly, genome-wide binding, and function of gene regulatory complexes that act over large chromosomal territories. We demonstrate that a subunit of C. elegans MLL/COMPASS, a g...
ORGANISM(S): Caenorhabditis elegans 
2011-03-01 | E-GEOD-25877 | biostudies-arrayexpress
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