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TranscriptomicsRNA-seq of coding RNA from DDX6 knockout human haploid (HAP1) cells
We performed a genome-scale screen for suppressors of interferon stimulated gene (ISG) expression in human haploid cells (HAP1). DEAD-box helicase 6 (DDX6) was a significant hit. In order to validate DDX6 as a regulator of ISG expression, we created knockouts of DDX6 in HAP1 cells using CRISPR-Cas9 ...
ORGANISM(S): Homo sapiens 
2017-07-25 | E-MTAB-5867 | biostudies-arrayexpress
ProteomicsIdentification of DDX6 ubiquitylated lysines in cAMP-stimulated cells. stimulation
DDX6 is an RNA helicase mostly located in the P-bodies, membrane-less organelles that play a fundamental role in the post-transcriptional regulation of gene expression. We found that stimulation of the G protein-coupled receptor (GPCR)-cAMP pathway induces a non-proteolytic polyubiquitylation of DDX...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD054750 | Pride
Dia Polyubiquitin P-bodies Camp Ddx6 Lc-ms/ms 
TranscriptomicsLarge-scale study of total and polysomial mRNA after DDX6 depletion in HEK293 cells
DDX6 is an abundant cytoplasmic DEAD-box RNA helicase which is involved in disparate aspects of mRNA stability and translation, leading to a confused understanding of its global function. We carried out a large-scale study of total and polysomial mRNA after DDX6 depletion to get an accurate picture ...
ORGANISM(S): Homo sapiens 
2017-09-28 | E-MTAB-4091 | biostudies-arrayexpress
GenomicsmRNA transcriptome analysis of Ddx6 knockout embryos
mRNA transcriptome analysis of Ddx6 knockout embryos
PRJNA718566 | ENA
TranscriptomicsRIP-Seq of An Integrated Signaling Network Controls P-Bodies Dynamics and mRNA Translation in Human Glioblastoma
Processing (P)-bodies are cytoplasmic membrane-less condensates including translationally repressed mRNAs and proteins involved in the mRNA decay machinery. The mechanisms underlying P-bodies nucleation and mRNA decay have been largely described. However, the impact of signaling networks in P-bodies...
ORGANISM(S): Homo sapiens 
2025-03-30 | E-MTAB-14331 | biostudies-arrayexpress
ProteomicsMOLM-13 DDX6 KD proteomics to study RNA sequestration in Pbodies
Proteomics data associated with DDX6-depleted MOLM-13 cell line to study RNA sequestration mechanism in leukemogenesis.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-27 | MSV000090973 | MassIVE
GenomicsHuman DDX6 regulates translation and decay of inefficiently translated mRNAs
Human DDX6 regulates translation and decay of inefficiently translated mRNAs
PRJNA970317 | ENA
GenomicsThe RNA helicase DDX6 regulation in human skeletal myoblasts [eCLIP-seq]
The RNA helicase DDX6 regulation in human skeletal myoblasts [eCLIP-seq]
PRJNA517602 | ENA
GenomicsRNA-seq of coding RNA from DDX6 knockout human haploid (HAP1) cells
RNA-seq of coding RNA from DDX6 knockout human haploid (HAP1) cells
PRJEB21725 | ENA
GenomicsDDX6 decouples translational repression from RNA degradation of miRNA targets [DDX6KO Polysome]
DDX6 decouples translational repression from RNA degradation of miRNA targets [DDX6KO Polysome]
PRJNA448917 | ENA
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