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ProteomicsBridge-like lipid transfer protein 3A (BLTP3A) is associated with membranes of the late endocytic pathway and is an effector of CASM
Recent studies have identified a family of rod-shaped proteins which includes VPS13 and ATG2 and are thought to mediate unidirectional lipid transport at intracellular membrane contacts by a bridge-like mechanism. Here, we show that one such protein, BLTP3A/UHRF1BP1, associates with VAMP7-positive v...
ORGANISM(S): Homo sapiens (Human) 
2025-08-28 | PXD056338 | Pride
Lysosome Lysosomal membrane damage Bltp Bltp3b Bltp3a Casm Rab7 Bridge-like lipid transfer protein 
ProteomicsSynaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates
Ectopic expression in fibroblasts of synapsin 1 and synaptophysin is sufficient to generate condensates of vesicles highly reminiscent of synaptic vesicle (SV) clusters and with liquid-like properties. We show that unlike synaptophysin, other major integral SV membrane proteins fail to form condensa...
ORGANISM(S): Cercopithecus aethiops (Green monkey) (Grivet) 
2022-12-24 | PXD037490 | Pride
Synaptophysin Synapsin Atg9a Sypnatic vesicle 
MetabolomicsInositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of membrane tethers to contact sites between the endoplasmic reticulum (ER) and the plasma membrane is often triggered by calcium. In contrast, we reveal here a funct...
2021-05-06 | MTBLS2444 | MetaboLights
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