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ProteomicsLabel-free differential proteomics analysis of Ba/F3 expressing WT and mutant R98S RPL10
We recently identified a recurrent mutation in the ribosomal gene RPL10 that results in substitution of residue arginine 98 by a serine (R98S) of the ribosomal protein L10 (RPL10) in the contest of T-cell acute lymphoblastic leukemia (T-ALL). To gain insights into the mechanisms by which the RPL10 R...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-28 | PXD005995 | Pride
Leukemia T-all Ribosomal mutation Rpl10 r98s 
ProteomicsMolecular characterization of ribosome defective cell lines
We generated a unique panel of isogenic cell models with the following genotypes via CRISPR-Cas9 engineering: Rpl5+/-, Rpl10 R98S, Rpl11+/-, Rpl22+/-, Rpl22-/-, Rps15 P131S and Rps15 H137Y. As cellular background, we chose for Ba/F3 cells. These are mouse lymphoid pro-B-cells, offering a relevant ce...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-18 | PXD051831 | Pride
Cancer Proteomics Mouse Ba/f3 Ribosome Crispr 
ProteomicsRUNX1 IP-MS on RPMI-8402 NKX2-1 +/+ and -/-
Unravel the binding partners of RUNX1 transcription factor in RPMI-8402 NKX2-1 +/+ and NKX2-1 -/-.
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD057654 | Pride
Human Nkx2-1 Runx1 Leukemia 
ProteomicsNKX2-1 IP-MS on RPMI-8402 NKX2-1 +/+ and -/-
Unravel the binding partners of NKX2-1 transcription factor in RPMI-8402 NKX2-1 +/+, using NKX2-1 -/- as negative control.
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD057622 | Pride
Human Nkx2-1 Leukemia 
Genomicsena-DATASET-VIB-CME-16-05-2014-16:10:17:695-121 - samples
Description not provided
EGAD00001000849 | EGA
GenomicsIdentification of point mutations, expression perturbations, and gene fusions in T-cell acute lymphoblastic leukemia by RNA-seq
RNA-seq is a promising technology to re-sequence protein-coding genes for the identification of single nucleotide variants, while simultaneously obtaining information on structural variations and gene expression perturbations. T-cell acute lymphoblastic leukemia (T-ALL) is caused by a combination of...
EGAS00001000536 | EGA
GenomicsVIB Institutional DAC
Data Access Committee EGAC00001002939
EGAC00001002939 | EGA
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