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MetabolomicsUntargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

INTRODUCTION: Interesting data about the family Asteraceae as a new source of Leishmania major dihydroorotate dehydrogenase (LmDHODH) inhibitors are presented. This key macromolecular target for parasites causing neglected diseases catalyzes the fourth reaction of the de novo pyr...

2019-10-14 | MTBLS722 | MetaboLights
TranscriptomicsSACL, a bHLH gene that restricts vascular cell proliferation in plants.
The final size and arrangement of the plant vasculature requires precise adjustment of cell proliferation. In particular, radial growth of vascular bundles is to a large extent controlled by a bHLH transcription factor heterodimer formed by TARGET OF MONOPTEROS5 (TMO5) and LONESOME HIGHWAY (LHW). Ex...
ORGANISM(S): Arabidopsis thaliana 
2015-09-01 | E-GEOD-70157 | biostudies-arrayexpress
ProteomicsMetaproteomic analysis of glacial ecosystem
Glaciers are populated by a large number of microorganisms including bacteria, archaea and microeukaryotes. From an ecological point of view, three ecosystems can be differentiated in glaciers: the supraglacial ecosystem, the subglacial ecosystem and the englacial ecosystem. Several factors such as ...
ORGANISM(S): environmental samples 
2019-08-29 | PXD010060 | Pride
Maldi-tof ms Glacier Culturomics Metaproteomics 
UnknownBeauveria bassiana: Quercetinase production and genetic diversity.
Not available
S-EPMC3768907 | biostudies-literature
TranscriptomicsThe Rpd3L HDAC complex is essential for the heat stress response in yeast
To ensure cell survival and growth during temperature increase, eukaryotic organisms respond with transcriptional activation that results in accumulation of proteins that protect against damage, and facilitate recovery. To define the global cellular adaptation response to heat stress, we performed a...
ORGANISM(S): Saccharomyces cerevisiae 
2010-04-23 | E-GEOD-17514 | biostudies-arrayexpress
ProteomicsMouse WAT mitochondrial bioenergetics LC-MSMS
Whether muscle mitochondrial dysfunction is the cause or consequence of metabolic disorders remains controversial. Herein, we demonstrate that inhibition of mitochondrial ATP synthase in muscle in vivo alters whole-body lipid homeostasis. Mice with restrained activity of the enzyme presented intrafi...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-06 | PXD017678 | Pride
Mouse wat 
ProteomicsSkeletal Muscle from Mice fed with HFD LC-MSMS
Whether muscle mitochondrial dysfunction is the cause or consequence of metabolic disorders remains controversial. Herein, we demonstrate that inhibition of mitochondrial ATP synthase in muscle in vivo alters whole-body lipid homeostasis. Mice with restrained activity of the enzyme presented intrafi...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-06 | PXD017683 | Pride
Mouse skeletal muscle hfd 
ProteomicsMouse Skeletal Muscle mitochondrial bioenergetics LC-MSMS
Whether muscle mitochondrial dysfunction is the cause or consequence of metabolic disorders remains controversial. Herein, we demonstrate that inhibition of mitochondrial ATP synthase in muscle in vivo alters whole-body lipid homeostasis. Mice with restrained activity of the enzyme presented intrafi...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-06 | PXD017621 | Pride
Mouse skeletal muscle 
ProteomicsSkeletal muscle wt and OXPHOS inhibited 18 months-old mice
TMT sixplex Isobaric Mass Tagging (TAM) analysis was carried out in the CBMSO Protein Chemistry Facility (ProteoRed, PRB3-ISCIII and UAM University, Spain. Chronic skeletal muscle mitochondria dyshomeostasis drives tubular aggregate formation.
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD026771 | Pride
Skeletal muscle soleus gastronecmius mice oxphos tubular agregate myopathy 
ProteomicsSkeletal muscle wt and OXPHOS inhibited 18 months-old mice treated with edaravone
Chronic skeletal muscle mitochondria dyshomeostasis drives tubular aggregate formation. TMT sixplex Isobaric Mass Tagging analysis was carried out in the CBMSO Protein Chemistry Facility (ProteoRed, PRB3-ISCIII and UAM University, Spain.
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD026722 | Pride
Soleus Oxphos Mouse skm Edaravone Tubular agregate myopathy 
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