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TranscriptomicsGene Expression in the Human Mammary Epithelium in response to consumption of high fat (H-FAT) and high carbohdyrate (H-CHO) diets.
Mammary gland (MG) de novo lipogenesis contributes significantly to milk fat in animals but little is known in humans. We hypothesized that de novo lipogenesis, as reflected by incorporation of 13C carbons from [U-13C]glucose into fatty acids (FAs) and glycerol in triglycerides (TG), will be greate...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-51874 | biostudies-arrayexpress
ProteomicsProAlanase is an effective alternative to trypsin for proteomics applications and disulfide bond mapping
Trypsin is the protease of choice in bottom-up proteomics. However, its application can be limited by the amino acid composition of target proteins and the pH of digestion solution. In this study we characterized ProAlanase, a protease from the fungus Aspergillus niger that cleaves primarily on the ...
ORGANISM(S): Homo sapiens (Human) Loxodonta africana (African elephant) 
2020-10-19 | PXD019039 | Pride
Sequence coverage Proline-rich Disulfide mapping Low-ph Proteomics Phosphorylation De novo sequencing Disulfide bonds Proalanase 
ProteomicsProAlanase is an effective alternative to trypsin for proteomics applications and disulfide bond mapping_part3
Trypsin is the protease of choice in bottom-up proteomics. However, its application can be limited by the amino acid composition of target proteins and the pH of the digestion solution. In this study we characterize ProAlanase, a protease from the fungus Aspergillus niger that cleaves primarily on t...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD021703 | Pride
Sequence coverage Proline-rich Low-ph Histones Proteomics Phosphorylation De novo sequencing Disulfide bonds Proalanase 
ProteomicsProAlanase is an effective alternative to trypsin for proteomics applications and disulfide bond mapping_part2
Trypsin is the protease of choice in bottom-up proteomics. However, its application can be limited by the amino acid composition of target proteins and the pH of digestion solution. In this study we characterized ProAlanase, a protease from the fungus Aspergillus niger that cleaves primarily on the ...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD021191 | Pride
Sequence coverage Proline-rich Disulfide mapping Low-ph Proteomics Phosphorylation De novo sequencing Disulfide bonds Histone ptms Proalanase Histone variants 
UnknownWhole-exome sequencing identifies de novo mutation in the COL1A1 gene to underlie the severe osteogenesis imperfecta.
Not available
S-EPMC4429824 | biostudies-literature
GenomicsRNA-directed DNA methylation in near-gene chromatin regulation
The purpose of this study was to measure DNA methylation and siRNA expression across the maize genome. The experimental data was derived from shotgun bisulfite sequencing, siRNA sequencing, and mRNA sequencing (Illumina, single end for all three)
ORGANISM(S): Zea mays 
2012-12-12 | E-MTAB-4329 | biostudies-arrayexpress
UnknownDe novo transcriptome sequencing and analysis of Anisakis pegreffii (Nematoda: Anisakidae) third-stage and fourth stage larvae.
Not available
S-EPMC7266050 | biostudies-literature
UnknownProAlanase is an Effective Alternative to Trypsin for Proteomics Applications and Disulfide Bond Mapping.
Not available
S-EPMC7710147 | biostudies-literature
ProteomicsCOL1 database samples for the Late Pleistocene of Western Eurasia
The project aimed to characterize the collagen type I (COL1) sequences from various modern, Holocene and Pleistocene bone, antler and skin samples for phylogenetic purposes. All extractions were performed at BioArCh, University of York (UK) or the Department of Human Evolution, MPI-EVA (Germany). An...
ORGANISM(S): Ursus americanus (American black bear) (Euarctos americanus) Capreolus capreolus (Roe deer) Aepyceros melampus Crocuta crocuta (Spotted hyena) Vulpes vulpes (Red fox) Castor fiber (Eurasian beaver) Capra ibex (Ibex) Cuon alpinus (Dhole) Panthera leo (Lion) Saiga tatarica (Saiga antelope) Cervus elaphus (Red deer) Meles meles (Eurasian badger) Gulo gulo (Wolverine) (Gluton) Rupicapra rupicapra (Chamois) Coelodonta antiquitatis (woolly rhinoceros) Lynx lynx (Eurasian lynx) (Felis lynx) Alces alces (Eurasian elk) Ursus maritimus (Polar bear) (Thalarctos maritimus) Lutra lutra (European river otter) Vulpes lagopus (Arctic fox) (Alopex lagopus) Megaloceros giganteus (Giant deer) (Alces gigantea) Axis axis (Axis deer) (Chital) Martes martes (European pine marten) Ursus arctos (Brown bear) (Grizzly bear) Rangifer tarandus (Reindeer) (Cervus tarandus) Equus hydruntinus 
2016-09-27 | PXD003190 | Pride
Lc-ms/ms Mammalia Q-exactive hybrid quadrupole-orbitrap ms De novo collagen sequencing 
UnknownDe Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects.
Not available
S-EPMC4825975 | biostudies-literature
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