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UnknownThe structure- and metal-dependent activity of Escherichia coli PgaB provides insight into the partial de-N-acetylation of poly-β-1,6-N-acetyl-D-glucosamine.
Not available
S-EPMC3438944 | biostudies-literature
UnknownStructural basis for the De-N-acetylation of Poly-β-1,6-N-acetyl-D-glucosamine in Gram-positive bacteria.
Not available
S-EPMC4276859 | biostudies-literature
TranscriptomicsRole of epigenetic modifiers on the bovine fibroblast innate immune response
The innate immune signaling pathway plays a crucial role in the recognition and early response to pathogens associated with disease. Genetic analysis has been unable to completely account for individual variability in the strength of the innate immune response. The aim of this study was to determine...
ORGANISM(S): Bos taurus 
2014-01-01 | E-GEOD-50405 | biostudies-arrayexpress
UnknownRegulation of selectin binding activity by cyclization of sialic acid moiety of carbohydrate ligands on human leukocytes.
Not available
S-EPMC15530 | biostudies-literature
UnknownIncreasing cell permeability of N-acetylglucosamine via 6-acetylation enhances capacity to suppress T-helper 1 (TH1)/TH17 responses and autoimmunity.
Not available
S-EPMC6435169 | biostudies-literature
ProteomicsAn integrated strategy reveals complex glycosylation of erythropoi-etin using top-down and bottom-up mass spectrometry
The characterization of therapeutic glycoproteins is challenging due to the structural micro- and macro-heterogeneity of the protein glycosylation. This study presents an in-depth strategy for glycosylation analysis using first-generation erythropoietin (epoetin beta), including a developed top-down...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-14 | PXD024835 | Pride
Erythropoietin Bottom-up Top-down Mass spectrometry Glycosylation Python scripts 
ProteomicsStructural and functional studies of CC chemokine receptor 5 phosphorylation and its interactions with arrestin2
The two non-visual arrestin isoforms, arrestin2 and arrestin3, recognize and bind hundreds of G protein-coupled receptors (GPCRs) with different phosphorylation patterns leading to distinct functional outcomes. Whereas the impact of phosphorylation of the vasopressin 2 receptor and rhodopsin on arre...
ORGANISM(S): Homo sapiens (Human) 
2023-05-24 | PXD036220 | Pride
Po4 
ProteomicsNAA15 haploinsufficiency can cause congenital heart disease and perturbs protein levels in induced pluripotent stem cells
NAA15 is a component of the NatA complex that acetylates amino terminal (Nt) protein residues and influences protein synthesis. We identified multiple damaging NAA15 variants in congenital heart disease patients, including four loss-of-function (LoF) variants, one missense (R276W) de novo variant an...
ORGANISM(S): Homo sapiens (Human) 
2021-08-30 | PXD018013 | Pride
Ipsc N-terminal acetylation N-terminomics 
GenomicsKAT6A mutations in Arboleda-Tham syndrome affect regulation and expression of HOXC genes [ATAC-seq]
Arboleda-Tham Syndrome (ARTHS) is a rare genetic disorder caused by heterozygous, de novo truncating mutations in the gene KAT6A (Lysine(K) acetyltransferase 6A). ARTHS is clinically heterogeneous but characterized by several common features including intellectual disability, developmental and speec...
ORGANISM(S): Homo sapiens 
2023-08-15 | GSE237020 | GEO
GenomicsKAT6A mutations in Arboleda-Tham syndrome affect regulation and expression of HOXC genes [ChIP-seq]
Arboleda-Tham Syndrome (ARTHS) is a rare genetic disorder caused by heterozygous, de novo truncating mutations in the gene KAT6A (Lysine(K) acetyltransferase 6A). ARTHS is clinically heterogeneous but characterized by several common features including intellectual disability, developmental and speec...
ORGANISM(S): Homo sapiens 
2023-08-15 | GSE237021 | GEO
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