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ProteomicsIdentification of deubiquitinases controlled by extracellular matrix stiffness in cancer cells
The project was aimed at identifying deubiquitinases (DUBs) involved in cancer cell mechanosignaling. Lysates from cancer cells grown on collagen matrices with varying stiffnesses were incubated with an activity-based HA-tagged ubiquitin probe that covalently binds DUB active site. To identify DUBs ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-22 | PXD054010 | Pride
Lc-ms/ms Immunopurification Dub abp Ecm stiffness 
ProteomicsTargeting DDR1 and DDR2 overcomes matrix-mediated melanoma cell adaptation to BRAF-targeted therapy
To investigate the contribution of fibroblast-derived extracellular matrices (ECMs) to the resistance to targeted therapies in BRAF-mutated melanoma cells, we generated native-like 3D ECMs from human primary fibroblasts obtained from healthy individuals or melanoma patients. Cell-derived matrices fr...
ORGANISM(S): Homo sapiens (Human) 
2021-11-12 | PXD026645 | Pride
Lc-msms Resistance Targeted therapies Melanoma Ddr Extracellular matrix 
UnknownFactors related to and economic implications of inhospital death in German lung cancer patients - results of a Nationwide health insurance claims data based study.
Not available
S-EPMC6194570 | biostudies-literature
UnknownSpatially resolved spectroscopic differentiation of hydrophilic and hydrophobic domains on individual insulin amyloid fibrils.
Not available
S-EPMC5030623 | biostudies-literature
UnknownIntracranial ependymoma: long-term results in a series of 21 patients treated with stereotactic (125)iodine brachytherapy.
Not available
S-EPMC3489891 | biostudies-literature
UnknownDeterminants and reference values of the 6-min walk distance in the general population-results of the population-based STAAB cohort study.
Not available
S-EPMC12408663 | biostudies-literature
UnknownDOX-DNA Interactions on the Nanoscale: In Situ Studies Using Tip-Enhanced Raman Scattering.
Not available
S-EPMC11154666 | biostudies-literature
UnknownEffect of census-based correction of population figures on mortality rates in Germany.
Not available
S-EPMC11773962 | biostudies-literature
UnknownEmerging Role of Deubiquitinating Enzymes (DUBs) in Melanoma Pathogenesis.
Not available
S-EPMC9322030 | biostudies-literature
UnknownOne Health Genomic Analysis of Extended-Spectrum β-Lactamase‒Producing Salmonella enterica, Canada, 2012‒2016.
Not available
S-EPMC9239887 | biostudies-literature
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