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MetabolomicsEndoplasmic reticulum-derived bodies enable a single-cell chemical defense in Brassicaceae plants
Brassicaceae plants have a dual-cell type of chemical defense against herbivory. Here we show a novel single-cell defense involving endoplasmic reticulum (ER)-derived organelles (ER bodies) and the vacuoles. We identify various glucosinolates as endogenous substrates of the ER-body β-glucosidases BG...
2020-02-04 | MTBLS1383 | MetaboLights
MetabolomicsDiurnal Dynamics Shape Plant Defense Responses: Temporal Variations in Disease Progression and Metabolic Reprogramming in Brassica oleracea
Plants synchronize their immune responses with the circadian cycle, yet the impact of diurnal timing on disease resistance remains poorly understood in crop species. In this study, we investigated how diurnal variation modulates defense responses in Brassica oleracea against Xanthomonas campestris p...
2025-08-22 | MTBLS7854 | MetaboLights
MetabolomicsDual transcriptomic & metabolomic analysis of elicited flax sheds light on the kinetics of immune defense activation against the biotrophic pathogen Oidium lini.
Flax (Linum usitatissimum) grown under controlled conditions displayed genotype-dependent resistance to powdery mildew (Oidium lini) following COS-OGA (comprising chitosan- and pectin-derived oligomers) elicitor application. The present study reveals a two-step immune response in plant...
2025-04-25 | MTBLS8263 | MetaboLights
MetabolomicsWe characterize the anti-phage function of a type IV TA system, ShosTA toxin-antitoxin system provides phage defense via DNA damage and repair
Widespread in bacteria and archaea, Toxin-antitoxin (TA) systems have been recently demonstrated to function in phage defense. Here we characterize the anti-phage function of a type IV TA system, ShosTA. Using structural and biochemical approaches, we show that ShosT couples phosphoribosyltransferas...
2025-02-17 | MTBLS11212 | MetaboLights
MetabolomicsExploring Pinus nigra's induced defense arsenal against Diplodia sapinea through genes and metabolic pathway analysis

Two years-old Pinus nigra saplings from two different provenances (Austria and Corsica) were infected with Diplodia sapinea. Needles from the terminal shoot (distant tissue where systemic induced response might take place) were sampled always in the morning. Samples were taken 3, 8 and 21 days af...

2026-01-12 | MTBLS13184 | MetaboLights
ProteomicsBroad and specific anti-defense genes in bacteriophage genomes
Bacteria and bacteriophages have been engaged in a relentless evolutionary arms race, driving a rapid evolution of bacterial defense mechanisms and leading to their scattered distribution across genomes. We hypothesized that the variability in defense systems presence in bacterial genomes leads to e...
ORGANISM(S): Pseudomonas aeruginosa AES-1R Bacteria 
2026-02-23 | PXD063439 | Pride
Bacterial immunity Defense systems Bacteriophage Dia proteomics 
ProteomicsA Phage Protein Kinase Subverts Bacterial Defense Systems through Hyperpromiscuous Phosphorylation
Bacteria and bacteriophages are in a constant arms race to develop bacterial defense and phage counter-defense systems. The prevailing view so far has been that phage counter-defense systems target specific bacterial defense systems. Here, we uncover a mechanism by which the T7 bacteriophage broadly...
ORGANISM(S): Escherichia coli 
2026-06-17 | PXD058408 | Pride
Phosphoproteomics Phage Defense systems 
TranscriptomicsCoordination of frontline defense mechanisms under severe oxidative stress.
Oxidative stress (OS) results from genetic defects or stressful environmental challenges that cause unchecked production of reactive oxygen species (ROS). OS has been implicated in many diseases due to its wide ranging damage to nucleic acids, proteins and lipids. Using Halobacterium salinarum NRC...
ORGANISM(S): Halobacterium salinarum 
2010-05-26 | E-GEOD-17515 | biostudies-arrayexpress
GenomicsNuclease-NTPase systems use shared molecular features to control bacterial anti-phage defense
Nuclease-NTPase systems use shared molecular features to control bacterial anti-phage defense
PRJNA1294728 | ENA
TranscriptomicsArabidopsis defense against Botrytis cinerea: chronology and regulation deciphered by high-resolution temporal transcriptomic analysis (tga3-2 knockout data)
Transcriptional reprogramming forms a major part of a plant's response to pathogen infection. Many individual components and pathways operating during plant defense have been identified but our knowledge of how these different components interact is still rudimentary. We have generated a high-resolu...
ORGANISM(S): Arabidopsis thaliana 
2012-10-03 | E-GEOD-39597 | biostudies-arrayexpress
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