Sort   by:  
 Page size 
ProteomicsRapid and accurate detection of aminoglycoside modifying enzymes and 16S ribosomal RNA methyltransferases by targeted LC-MS/MS
New and rapid diagnostic methods are needed for the detection of antimicrobial resistance to aid in the curbing of drug-resistant infections. Targeted LC-MS/MS is a method that could serve this purpose, as it can detect specific peptides of resistance mechanisms with high accuracy. In the current st...
ORGANISM(S): Escherichia coli Klebsiella pneumoniae BIDMC 40 
2021-04-30 | PXD024339 | Pride
E. coli Aminoglycosides Parallel reaction monitoring Aminoglycoside modifying enzymes Liquid chromatography mass spectrometry K. pneumoniae 16s ribosomal rna methyltransferases Antimicrobial resistance 
ProteomicsMetabolic changes related to the IDH1 mutation in gliomas preserve TCA-cycle activity: an investigation at the protein level
The discovery of the IDH1 R132H (IDH1 mut) mutation in low-grade glioma and the associated change in function of the IDH1 enzyme has increased the interest in glioma metabolism. In an earlier study, we found that changes in expression of genes involved in the aerobic glycolysis and the TCA-cycle are...
ORGANISM(S): Homo sapiens (Human) 
2020-03-09 | PXD016697 | Pride
Proteomics Glioma Idh1 mutation 
ProteomicsMetabolic changes related to the IDH1 mutation in gliomas preserve TCA-cycle activity: an investigation at the protein level
The discovery of the IDH1 R132H (IDH1 mut) mutation in low-grade glioma and the associated change in function of the IDH1 enzyme has increased the interest in glioma metabolism. In an earlier study, we found that changes in expression of genes involved in the aerobic glycolysis and the TCA-cycle are...
ORGANISM(S): Homo sapiens (Human) 
2020-03-09 | PXD016698 | Pride
Metabolism Idh1 Proteomics Glioma 
ProteomicsLC-MS/MS analysis demonstrates a decrease in porins and increase in CMY-2-like beta-lactamases in E. coli exposed to meropenem
While ESBL and AmpC beta-lactamases barely degrade carbapenems, they are able to bind them and prevent them from interacting with penicillin binding proteins thereby preventing their effect. When these beta-lactamases are expressed at a high level and combined with a decreased influx of carbapenems ...
ORGANISM(S): Escherichia coli 
2022-04-04 | PXD025363 | Pride
E. coli Cmy-2-like Liquid chromatography-mass spectrometry Ompc Meropenem Parallel reaction monitoring Chromosomal ampc Ompf Antimicrobial resistance 
Sort   by:  
 Page size