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ProteomicsProteomics of human cord blood reticulocyte-derived exosomes
Human reticulocytes were enriched from human umbilical blood, and cultured in vitro for the production of reticulocyte-derived exosomes (HuRex)to unveil their proteomic composition. As research on the molecular-cargo of exosomes is largely confounded by the lack of a “gold-standard” methodology, we ...
ORGANISM(S): Homo sapiens (Human) 
2018-09-24 | PXD008545 | Pride
Human Lc-msms Exosome Reticulocyte 
ProteomicsProteomic characterization of plasma-derived exosomes from P. vivax infected FRG huHep mice
This project focused in the proteomic characterization of plasma-derived exosomes from Plasmodium vivax infected FRG huHep mice, a suitable in vivo model for the development of pre-erythrocytic stages of this parasite. P. vivax is responsible for the vast majority of Malaria cases outside Africa. Th...
ORGANISM(S): Plasmodium vivax Homo sapiens (Human) Mus musculus (Mouse) 
2018-07-16 | PXD008945 | Pride
Exosomes Plasmodium vivax Humanized liver chimeric mouse 
TranscriptomicsTime series of Balb/c spleen infected with Plasmodium yoelii non-lethal vs lethal strains
Knowledge on the dynamic features of the processes driven by malaria parasites in the spleen, our biggest lymphoid organ, is lacking. We have implemented intravital microscopy and magnetic resonance imaging of the mouse spleen in experimental infections with the Plasmodium yoelii non-lethal (17X) an...
ORGANISM(S): Mus musculus 
2010-10-12 | E-GEOD-17603 | biostudies-arrayexpress
ProteomicsProteomic characterization of exosomes derived from malaria-infected reticulocytes, in a murine malaria model
Reticulocyte-derived exosomes (rex) are 30-100 nm membrane vesicles of endocytic origin released during the maturation of reticulocytes to erythrocytes upon fusion of multivesicular bodies with the plasma membrane. We previously found that immunization of mice with rex from BALB/c mice infected with...
ORGANISM(S): Mus musculus (Mouse) Plasmodium yoelii 
2018-10-26 | PXD005048 | Pride
Reticulocytes Malaria Exosomes Spleen 
ProteomicsExploring Diverse Clinical Presentations in COVID-19 through Circulating Extracellular Vesicle Proteomics Analysis
Extracellular vesicles (EVs) released by virus-infected cells are susceptible to incorporate viral peptides. Here, we hypothesized that the molecular characterization of EVs obtained from COVID-19 patients will reveal novel immunogenic viral peptides. Blood from COVID-19 patients with severe (G1), m...
ORGANISM(S): Homo sapiens (Human) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2024-09-25 | PXD041931 | Pride
Proteomics profiling Covid-19 patients Clinical data Ganglioside-capture(siglec-1) Antibody response Extracellular vesicles Size-exclusion chromatography(sec) Tandem mass tag(tmt) Immunocapture(cd9) 
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