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TranscriptomicsReticulocyte 3 timepoints
Mouse models have proven invaluable for understanding erythropoiesis. Here, we describe an autosomal recessive inherited anemia in the mouse mutant hem6. Hematologic and transplantation analyses revealed a mild, congenital, hypochromic, microcytic anemia intrinsic to the hematopoietic system that is...
ORGANISM(S): Mus musculus 
2009-10-12 | E-GEOD-16174 | biostudies-arrayexpress
ProteomicsProteomics of human cord blood reticulocyte-derived exosomes
Human reticulocytes were enriched from human umbilical blood, and cultured in vitro for the production of reticulocyte-derived exosomes (HuRex)to unveil their proteomic composition. As research on the molecular-cargo of exosomes is largely confounded by the lack of a “gold-standard” methodology, we ...
ORGANISM(S): Homo sapiens (Human) 
2018-09-24 | PXD008545 | Pride
Human Lc-msms Exosome Reticulocyte 
ProteomicsProteomic characterization of exosomes derived from malaria-infected reticulocytes, in a murine malaria model
Reticulocyte-derived exosomes (rex) are 30-100 nm membrane vesicles of endocytic origin released during the maturation of reticulocytes to erythrocytes upon fusion of multivesicular bodies with the plasma membrane. We previously found that immunization of mice with rex from BALB/c mice infected with...
ORGANISM(S): Mus musculus (Mouse) Plasmodium yoelii 
2018-10-26 | PXD005048 | Pride
Reticulocytes Malaria Exosomes Spleen 
ProteomicsNanoLC-MSMS TMT comparison of circulated and unstimulated in vitro cultured reticulocytes
Triplicate samples of unstimulated in vitro culture-derived reticulocytes (derived from CD34+ cells) and cultured reticulocytes circulated overnight in an ex vivo circulation system were analysed through TMT-based quantitative proteomics to explore the impact of shear stress on reticulocyte protein ...
ORGANISM(S): Homo sapiens (Human) 
2018-08-03 | PXD009024 | Pride
Human Reticulocyte Nanolc-msms Erythrocyte Erythropoiesis 
ProteomicsNanoLC-MSMS TMT comparison of in vitro cultured/native reticulocytes and erythrocytes
Triplicate samples of donor-matched native reticulocytes (CD71+ cells), erythrocytes (CD71- cells) and in vitro culture-derived reticulocytes (derived from CD34+ cells) were analysed through TMT-based quantitative proteomics to examine possible protein abundance changes underlying reticulocyte matur...
ORGANISM(S): Homo sapiens (Human) 
2018-08-03 | PXD009023 | Pride
Human Reticulocyte Nanolc-msms Erythrocyte Erythropoiesis 
ProteomicsNanoLC-MSMS Phosphoproteomics comparison of in vitro cultured/native reticulocytes and erythrocytes
Triplicate samples of donor-matched native reticulocytes (CD71+ cells), erythrocytes (CD71- cells) and in vitro culture-derived reticulocytes (derived from CD34+ cells) were analysed through qualitative phosphoproteomics to examine possible novel mechanisms underlying reticulocyte maturation.
ORGANISM(S): Homo sapiens (Human) 
2018-08-03 | PXD009015 | Pride
Human Phospho Reticulocyte Nanolc-msms Erythrocyte Erythropoiesis 
TranscriptomicsThe human reticulocyte transcriptome
RNA from circulating blood reticulocytes was utilized to provide a robust description of genes transcribed at the final stages of erythroblast maturation. After depletion of leukocytes and platelets, Affymetrix HG-U133 arrays were hybridized with probe from total RNA isolated from blood sampled from...
ORGANISM(S): Homo sapiens 
2007-03-26 | GSE6236 | GEO
TranscriptomicsTranscription profiling of human circulating blood reticulocytes from adult and cord blood to provide a robust description of genes transcribed at the final stages of erythroblast maturation
RNA from circulating blood reticulocytes was utilized to provide a robust description of genes transcribed at the final stages of erythroblast maturation. After depletion of leukocytes and platelets, Affymetrix HG-U133 arrays were hybridized with probe from total RNA isolated from blood sampled from...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-6236 | biostudies-arrayexpress
UnknownTargeting a Reticulocyte Binding Protein and Duffy Binding Protein to Inhibit Reticulocyte Invasion by Plasmodium vivax.
Not available
S-EPMC6043553 | biostudies-literature
TranscriptomicsThe human reticulocyte transcriptome (HG-U133_Plus2.0)
RNA from circulating blood reticulocytes was utilized to provide a robust description of genes transcribed at the final stages of erythroblast maturation. After depletion of leukocytes and platelets, Affymetrix HG-U133Plus 2.0 arrays were hybridized with probe from total RNA isolated from blood samp...
ORGANISM(S): Homo sapiens 
2009-11-30 | E-GEOD-17639 | biostudies-arrayexpress
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