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ProteomicsCaldendrin regulates spine apparatus localization through myosin V-dependent ER-stabilization in dendritic spines
Excitatory synapses of principal hippocampal neurons are frequently located on dendritic spines. The dynamic strengthening or weakening of individual inputs results in a great structural and molecular diversity of dendritic spines. Active spines with large Ca2+-transients are frequently invaded by a...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-01-27 | PXD029427 | Pride
Spine apparatus Myosin V-dependent er-stabilization Caldendrin Dendritic spines 
ProteomicsPin1 mediates Ab42-mediated dendritic spine loss
Early-stage Alzheimer's disease is characterized by the loss of dendritic spines in the neocortex of the brain. This phenomenon precedes tau pathology, plaque formation, and neurodegeneration and likely contributes to synaptic loss, memory impairment, and behavioral changes in patients. Studies sugg...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-02-14 | MSV000082066 | MassIVE
ProteomicsPU.1 interactome mouse bone marrow derived dendritic cells
Mouse bone marrow derived dendritic cells were generated by culturing bone marrow cells at a density of 0.5x10E6 cells/ml in RPMI-1640 supplemented with 5% FCS, 1% Pen/Strep, 5microM 2-mercaptoethanol, 20ng/ml GM-CSF. At day 7 dendritic cells were stimulated or not with 500 ng/ml LPS, and collected ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-11-30 | MSV000083176 | MassIVE
ProteomicsSequential elution interactome analysis of Mind bomb 1 and a novel role in dendritic spine outgrowth
Mind bomb 1 (Mib1) is an E3 ubiquitin-ligase that is essential for overall metazoan development, including multiple stages of neuronal development. It is located in puncta throughout neurons, including near post synaptic densities (PSD), and has been shown to participate in several signaling pathway...
ORGANISM(S): Homo sapiens (Human) 
2016-07-06 | PXD001255 | Pride
Proteomics Mass spectrometry Notch signaling Wnt signaling Neuronal morphogenesis Dendritic spines Affinity purification E3 ligase Endocytosis Interactome 
TranscriptomicsNLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells
Effect of Monosodium Urate Crystals in wild-type and NLRP3 ko murine dendritic cells
ORGANISM(S): Mus musculus 
2013-07-11 | E-MEXP-3858 | biostudies-arrayexpress
TranscriptomicsStimulation of dendritic cells with heat-killed Candida albicans
Monocyte-derived dendritic cells obtained from healthy donors were collected and either left untreated, or treated for three hours with heat-killed Candida albicans. Three distinct donors were used. Related data sets have been deposited in ArrayExpress under accessions E-MTAB-750 and E-MTAB-1213
ORGANISM(S): Homo sapiens 
2012-01-01 | E-MTAB-751 | biostudies-arrayexpress
TranscriptomicsEffects of Carbon Nanotubes Substrates on dendritic cells
To assess the effect of carbon nanotubes substrated on dendritic cell (DCs) properties, DCs were generated from human monocytes of healthy donors as previously described (Aldinucci A et al, 2010). In particular, isolated monocytes were cultured for 6 days in medium supplemented with GM-CSF (1000U/ml...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-MEXP-3560 | biostudies-arrayexpress
TranscriptomicsCocaine Regulates MEF2 to Control Synaptic and Behavioral Plasticity
Repeated exposure to cocaine causes sensitized behavioral responses and increased dendritic spines on medium spiny neurons of the nucleus accumbens (NAc). We find that cocaine regulates myocyte enhancer factor 2 (MEF2) transcription factors to control these two processes in vivo. Cocaine suppresses ...
ORGANISM(S): Mus musculus 
2008-08-24 | E-GEOD-11939 | biostudies-arrayexpress
TranscriptomicsStimulation of dendritic cells with LPS and R848
Samples of monocyte derived dendritic cells (moDCs) from three healthy volunteers untreated and treated with LPS [100ng/ml] or R848 [2.5µg/ml] for different time points (0h,3h,6h,12h and 24h).
ORGANISM(S): Homo sapiens 
2010-12-03 | E-MTAB-448 | biostudies-arrayexpress
TranscriptomicsFine-tuning of human dendritic cells regulation revealed by translational profiling
Dendritic cells (DCs) are the sentinels of the mammalian immune system and they undergo a complex maturation process mediated by activation upon pathogen detection. Recent studies described the analysis of activated DCs by transcriptional profiling, but translation regulation was never taken in acco...
ORGANISM(S): Homo sapiens 
2009-12-30 | E-GEOD-14000 | biostudies-arrayexpress
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