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UnknownJian-Pi-Yi-Shen Formula Improves Adenine-Induced Chronic Kidney Disease via Regulating Tryptophan Metabolism and Aryl Hydrocarbon Receptor Signaling.
Not available
S-EPMC9294467 | biostudies-literature
UnknownJian-Pi-Yi-Shen formula alleviates renal fibrosis by restoring NAD+ biosynthesis in vivo and in vitro.
Not available
S-EPMC10817388 | biostudies-literature
UnknownJian-Pi-Yi-Shen formula enhances perindopril inhibition of chronic kidney disease progression by activation of SIRT3, modulation of mitochondrial dynamics, and antioxidant effects.
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S-EPMC8536834 | biostudies-literature
ProteomicsGlutathionylation decreases methyltransferase activity of PRMT5 and inhibits cell proliferation
Glutathionylation is an important posttranslational modification that protects proteins from further oxidative damage as well as influencing protein structure and activity. In the present study, we demonstrate that the cysteine-42 residue in protein arginine N-methyltransferase 5 (PRMT5) is glutathi...
ORGANISM(S): Homo sapiens (Human) 
2020-09-02 | PXD020428 | Pride
Glutathionylation Methyltransferase activity Protein arginine n-methyltransferase 5 (prmt5) Reactive oxygen species (ros) Binding affinity 
ProteomicsDown-regulation of Rab 5C-dependent Endocytosis and Glycolysis in Cisplatin-resistant Ovarian Cancer Cell Lines
Drug resistance poses a major challenge to ovarian cancer treatment. Understanding mechanisms of drug resistance is important for finding new therapeutic targets. In the present work, a cisplatin-resistant ovarian cancer cell line A2780-DR was established with a resistance index of 6.64. The cellula...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080724 | MassIVE
UnknownMind matters: a comparative study of self-reported severity of depression and cognitive symptoms in China and the USA.
Not available
S-EPMC11927148 | biostudies-literature
ProteomicsLicorice Ameliorates Cisplatin-Induced Hepatotoxicity through Anti-apoptosis, Anti-oxidative Stress, Anti-inflammation, and Acceleration of Metabolism
Cisplatin (CP) is one of the most effective antitumor drugs in the clinic, but has serious adverse reactions, and its hepatotoxicity has not been fully investigated. Licorice (GC), a traditional herbal medicine, has been commonly used as a detoxifier for poisons and drugs, and may be an effective dr...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-11-27 | PXD021688 | Pride
Proteomics Hepatotoxicity Detoxification Cisplatin Licorice 
ProteomicsProfiling Glutathionylome in CD38-mediated Epithelial-Mesenchymal Transition
We engineered a cell system in which the glutathione synthetase (GS) mutant was expressed that catalyzed the formation of a glutathione analogy from azido-alanine to profile changes of glutathionylome in CD38-overexpressing cells.
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD032233 | Pride
Cd38 glutathionylome epithelial-mesenchymal transition 
ProteomicsDown-regulation of Vimentin Increased Drug Resistance in Ovarian Cancer Cells
Cisplatin and other platinum-based drugs are widely used in the treatment of ovarian cancer, but most patients acquire the drug resistance that greatly compromises the efficacy of drugs. Understanding the mechanism of drug resistance is important for finding new therapeutic approaches. In the presen...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002825 | Pride
Ovarian cancer cell line  drug-resistance  proteomics  vimentin  cisplatin 
UnknownmTOR-mediated glycolysis contributes to the enhanced suppressive function of murine tumor-infiltrating monocytic myeloid-derived suppressor cells.
Not available
S-EPMC11028128 | biostudies-literature
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