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TranscriptomicsMolecular consequences of Dlx3 deletion in mouse enamel organ as determined by RNASeq analysis
DLX3 is a homeodomain transcription factor involved in ameloblast differentiation and enamel formation. Mutations in DLX3 in human lead to defects in enamel. However, the downstream targets of Dlx3 transcriptional activity in the enamel organ have not been identified yet. In this study, we compared ...
ORGANISM(S): Mus musculus 
2015-05-14 | E-GEOD-57984 | biostudies-arrayexpress
ProteomicsDecontamination of archaeological dental enamel for palaeoproteomics
Archaeological materials will accumulate contamination from sources such as handling and storage, which may affect downstream analyses. For dental enamel, it has often been assumed that removal of contamination is not necessary prior to palaeoproteomic analyses, due to the extraction protocols that ...
ORGANISM(S): Coelodonta antiquitatis (woolly rhinoceros) 
2025-12-15 | PXD064417 | Pride
Dental enamel Contamination Archaeology Pleistocene Palaeoproteomics 
ProteomicsAutomated high-throughput biological sex identification from archaeological human dental enamel using targeted proteomics
Biological sex is a key information for archaeological and forensic studies, which can be assessed in enamel using proteomics. However, the lack of a standard approach for fast and accurate sex identification limits the reach of proteomics applications. Here, we introduce a targeted proteomics-based...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD049326 | Pride
Forensics Prm Sex Palaeoproteomics Archaeology Enamel 
TranscriptomicsTranscription profiling of mouse incisor tooth germ to associate changes in levels of mRNAs with development of enamel structure
The tooth is a convenient experimental model for the study of the basic mechanisms of organ development, including differentiation, cellular interaction, morphogenesis, and production and mineralization of extracellular matrices. The rodent incisor teeth grow continuously and exhibit all stages of t...
ORGANISM(S): Mus musculus 
2010-10-01 | E-MTAB-149 | biostudies-arrayexpress
ProteomicsEnamel proteome shows that Gigantopithecus was an early diverging pongine
Gigantopithecus blacki was a giant hominid that inhabited Southeast Asia during the Pleistocene. Its evolutionary relationship to other great ape species, and their divergence during the Middle and Late Miocene (16-5.3 Mya), remains disputed. In part, this is due to the absence of cranial and postcr...
ORGANISM(S): Hominidae 
2019-11-12 | PXD013838 | Pride
Enamel Pleistocene Gigantopithecus Lc-msms 
ProteomicsEarly Pleistocene enamel proteome sequences from Dmanisi resolve Stephanorhinus phylogeny
Ancient DNA (aDNA) sequencing has enabled reconstruction of speciation, migration, and admixture events for extinct taxa. Outside the permafrost, however, irreversible aDNA post-mortem degradation has so far limited aDNA recovery to the past ~0.5 million years (Ma). Contrarily, multiple analyses sug...
ORGANISM(S): Stephanorhinus Equus sp. Bison 
2019-09-11 | PXD011008 | Pride
Enamel Dmanisi Bone Palaeoproteomics Stephanorhinus Dentine Lc-ms/ms 
ProteomicsEnamel proteins reveal biological sex and intrataxon variability within Paranthropus robustus
The evolutionary relationships among extinct African hominin species are highly debated and largely unresolved, due in part to a lack of molecular data. Even within taxa, it is not always clear, based on morphology alone, whether ranges of variation are due to sexual dimorphism versus potentially un...
ORGANISM(S): Homo 
2025-06-09 | PXD040221 | Pride
Human evolution Sequence reconstruction Dental enamel Palaeoproteomics Enamel 
TranscriptomicsBmi1 mutant vs. WT dental epithelia
Transcriptional profiling of Bmi1 mutant dental epithelia including the stem cell compartment to determine which genes are upregulated in response to loss of Bmi1. Two condition experiment: dental epithelia homozygous null for Bmi1 and WT dental epithelia. 4 replicates each
ORGANISM(S): Mus musculus 
2013-04-12 | E-GEOD-45999 | biostudies-arrayexpress
TranscriptomicsInfluence of the two different cryopreservation methods to inflammation of dental pulp cells
Dental pulp cells of cryopreserved teeth (slow and rapid speed) were examined with microarray for screening which gene is involve in the inflammation process during the cryopreservation process. Intact caries-free, freshly extracted premolars (n=6) were collected from 3 patients for microarray assay...
ORGANISM(S): Homo sapiens 
2013-03-27 | E-GEOD-45502 | biostudies-arrayexpress
UnknownNovel methodology for measuring intraoral wear in enamel and dental restorative materials.
Not available
S-EPMC7745065 | biostudies-literature
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