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TranscriptomicsHypoxia-enhanced Derivation of iPSCs from Human Dental Pulp Cells
Hypoxia enhances the reprogramming efficiency of human dermal fibroblasts to become induced pluripotent stem cells (iPSCs). Because we showed previously that the hypoxia facilitates the isolation and maintenance of human dental pulp cells (DPCs), we examined here whether it promotes the reprogrammin...
ORGANISM(S): Homo sapiens 
2013-09-03 | E-GEOD-45872 | biostudies-arrayexpress
ProteomicsProteomic profile of human stem cells from dental pulp and periodontal ligament
Dental stem cells isolated from oral tissues have been shown to provide with high proliferation ability and multi-lineage differentiation potential. Although the dental stem cells possess the potential of nerve regeneration, the specific expression profile of dental pulp stem cells (DPSCs) and perio...
ORGANISM(S): Homo sapiens (Human) 
2021-06-10 | PXD021997 | Pride
Quantitative proteomics  2de  dpscs  pdlscs  nerve regeneration 
TranscriptomicsTranscription profiling of human dental pulp stem cells in long term culture
In previous studies, human dental pulp stem cells (hDPSCs) were mainly isolated from adults. In this manuscript, we tried characterization of hDPSCs isolated from an earlier developmental stage to evaluate potential usage of these cells for tissue regenerative therapy. hDPSCs isolated at the crown-c...
ORGANISM(S): Homo sapiens 
2008-04-08 | E-GEOD-10444 | biostudies-arrayexpress
TranscriptomicsEffect of EtOH on transcriptome signatures in human dental pulp stem cells
We have performed gene expression microarray analysis to profile transcriptomic signatures affected by EtOH in human dental pulp stem cells Established human dental pulp stem cells were treated with different dose of EtOH (0, 1, 5, 10, 20 and 50mM) for a different time periods (24 and 48 hrs). Total...
ORGANISM(S): Homo sapiens 
2014-05-03 | E-GEOD-57255 | biostudies-arrayexpress
TranscriptomicsRNA-seq Analysis of Control DPSC and DPSC Derived Neurons
A major challenge to the study and treatment of neurogenetic syndromes is the difficulty in gaining access to live neurons from individuals with these disorders. Although other sources of stem cells are currently available for differentiation into neurons, these can involve invasive procedures and b...
ORGANISM(S): Homo sapiens 
2016-08-08 | E-GEOD-67124 | biostudies-arrayexpress
TranscriptomicsOdontoblast-like cells and dental pulp fibroblasts stimulated with LTA, poly(I:C) and LPS.
Odontoblasts and fibroblasts are suspected to influence the innate immune response triggered in the dental pulp by micro-organisms that progressively invade the human tooth during the carious process. To determine whether they differ in their responses to oral pathogens, we performed a systematic co...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-9560 | biostudies-arrayexpress
ProteomicsDifferent osteogenic differentiation behavior of canine mesenchymal stem cells derived from bone marrow and dental pulp: the proteomics profile
Although various sources of cMSCs show similar characteristics, they are different in osteogenic potential due to their original cellular sources. Thus, this study was designed to globally explore and analyze the in vitro differentiation potential and behavior of canine bone-marrow derived mesenchym...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2021-09-08 | PXD015512 | Pride
Osteogenic differentiation Canine bone-marrow derived mesenchymal stem cells (cbm-mscs) Canine dental pulp stem cells (cdpscs) Systems biology 
TranscriptomicsExpression status of mRNA for sex hormone receptors in human dental pulp cells and the response to sex hormones in the cells
Objectives: Sex hormone receptors are reported to be present in human dental pulp (HDP) cells. The purpose of this study was to examine the biological significance of estrogen and androgen receptors (ER and AR, respectively) in HDP cells. Design: We isolated HDP cells expressing ER- and AR-mRNAs an...
ORGANISM(S): Homo sapiens 
2013-03-28 | E-GEOD-44677 | biostudies-arrayexpress
ProteomicsTooth Decay Promotes Senescence in Dental Pulp Stem Cells, Modifying Their Biological and Proteomic Profiles
Tooth decay, also known as dental caries, is a prevalent oral health problem that significantly reduces an individual's quality of life; however, it can be effectively managed through restorative treatments. The condition primarily affects the enamel and dentin structures and can be treated before i...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD064565 | Pride
Dental caries Senescence Tooth decay Dpsc 
ProteomicsDental Pulp Stem Cells LC-MS/MS analysis
This study focuses on the impact of ECM (extra-cellular matrix) over cell processes such as proliferation, differentiation or mineralization which is more specifically related to our dental pulp cells. We cultured these dental pulp stem cells (DPSC) in mineralization growth or normal growth conditio...
ORGANISM(S): Homo sapiens (Human) 
2021-09-23 | PXD018951 | Pride
Oral mucosa Mineralization Extracellular matrix Proteomics Cell differentiation Dental pulp 
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