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GenomicsDeoxyhypusine Synthase Promotes a Pro-Inflammatory Macrophage Phenotype
Deoxyhypusine Synthase Promotes a Pro-Inflammatory Macrophage Phenotype
PRJNA604198 | ENA
ProteomicsEvaluation of N8-propargyl spermidine and spermine as substrates of deoxyhypusine synthase in the in vitro hypusination of eIF5A and RIPK1
eIF5A is a well-established protein substrate of deoxyhypusine synthase (DHS), which also requires spermidine as a small-molecule substrate. At the end of 2024, a publication claimed that RIPK1 is an additional DHS substrate and that N8-propargyl spermidine can also serve as a DHS substrate. To eval...
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD071577 | Pride
N8-propargyl spermidine Dhs Eif5a Chemical probe Hypusination Deoxyhypusine synthase Ripk1 
ProteomicsDeoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development
Pancreatic diseases including diabetes and exocrine insufficiency would benefit from therapies that reverse cellular loss and/or restore cellular mass. The identification of molecular pathways that influence cellular growth is therefore critical for future therapeutic generation. Deoxyhypusine synth...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-10-30 | MSV000099697 | MassIVE
MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
UnknownEssential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development.
Not available
S-EPMC3220921 | biostudies-literature
UnknownDevelopment of an activity assay for characterizing deoxyhypusine synthase and its diverse reaction products.
Not available
S-EPMC7780104 | biostudies-literature
UnknownMolecular cloning and functional expression of human deoxyhypusine synthase cDNA based on expressed sequence tag information.
Not available
S-EPMC1217213 | biostudies-literature
UnknownIdentification and characterization of a novel deoxyhypusine synthase in Leishmania donovani.
Not available
S-EPMC2804193 | biostudies-literature
UnknownCloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax.
Not available
S-EPMC1654163 | biostudies-literature
UnknownAllosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog.
Not available
S-EPMC3663545 | biostudies-literature
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