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ModelsDel_Conte_Zerial2008_Rab5_Rab7_cut_out_switch
Cut-out switch model Membrane identity and GTPase cascades regulated by toggle and cut-out switches Perla Del Conte-Zerial, Lutz Brusch, Jochen C Rink, Claudio Collinet, Yannis Kalaidzidis, Marino Zerial, and Andreas Deutsch: ...
2024-09-02 | BIOMD0000000174 | BioModels
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
ProteomicsDetection and isolation of circulating tumor cells from breast cancer patients using CUB domain-containing protein 1 (CDCP1) Detection and isolation of circulating tumor cells from breast cancer patients using CUB domain-containing protein 1 (CDCP1) Detection and isolation of circulating tumor cells from breast cancer patients using CUB domain-containing protein 1 (CDCP1)
Circulating tumor cells (CTCs) and disseminated tumour cells with mesenchymal traits are difficult to detect by epithelial marker proteins. Particularly, triple negative breast cancers (TNBC) that are prone to therapy failure release a subpopulation of circulating tumour cells (CTCs) with mesenchyma...
ORGANISM(S): Homo sapiens (Human) 
2023-03-20 | PXD035203 | Pride
Breast cancer Cdcp1 Bone marrow Circulating tumour cells Dissemination 
UnknownDiscovery of a sushi domain-containing protein 2-positive phenotype in circulating tumor cells of metastatic breast cancer patients.
Not available
S-EPMC11785953 | biostudies-literature
MetabolomicsAutomated Label-free Quantification of Metabolites from Liquid Chromatography–Mass Spectrometry Data (Plasma)

Liquid chromatography coupled to mass spectrometry (LC-MS) has become a standard technology in metabolomics. In particular, label-free quantification based on LC-MS is easily amenable to large-scale studies and thus well suited to clinical metabolomics. Large-scale studies, however, require autom...

2015-12-16 | MTBLS234 | MetaboLights
ProteomicsFasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergism
Cancer cells voraciously consume nutrients to support their growth, exposing a metabolic vulnerability that can be therapeutically exploited. Here we show in hepatocellular carcinoma (HCC) cells, xenografts, and in patient-derived HCC organoids that fasting can synergistically sensitise resistant HC...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-02-16 | PXD022723 | Pride
Xenografts Starvation Hcc Sorafenib Tp53 Hepg2 
ModelsSpatio-temporal dynamics of Rab5 domains on the membrane of early endosomes
Spatio-temporal dynamics of Rab5 domains on the membrane of early endosomes
2018-06-08 | 322 | FAIRDOMHub
ModelsMorpheus model of spatio-temporal Smo regulation in response to Hh signaling
Morpheus model of spatio-temporal Smo regulation in response to Hh signaling
2018-06-08 | 321 | FAIRDOMHub
ProteomicsProteomeTools
The ProteomeTools project aims to derive molecular and digital tools from the human proteome to facilitate biomedical and life science research. Here, we describe the generation and multimodal LC-MS/MS analysis of >350,000 synthetic tryptic peptides representing nearly all canonical human gene produ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-02-10 | MSV000080544 | MassIVE
ModelsMorpheus: open source modelling and simulation framework for multicellular systems
Morpheus: open source modelling and simulation framework for multicellular systems
2018-06-08 | 320 | FAIRDOMHub
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