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UnknownFast Track Pathway to Accelerated Cholecystectomy Versus Standard of Care for Acute Cholecystitis (FAST) pilot trial.

Background

Timing to surgery for acute cholecystitis remains variable, ranging from early (< 7 d) to delayed surgery (> 7 d). Accelerated surgery may result in better outcomes owing to reduced exposure to hypercoagulable and inflammatory states. We sought to determine the feasibility of a tr...
S-EPMC11999720 | biostudies-literature
UnknownPreoperative levels of natriuretic peptides and the incidence of postoperative atrial fibrillation after noncardiac surgery: a prospective cohort study.

Background

Postoperative atrial fibrillation (POAF) is associated with clinically significant short- and long-term complications after noncardiac surgery. Our aim was to describe the incidence of clinically important POAF after noncardiac surgery and establish the prognostic value of N-termi...
S-EPMC7721376 | biostudies-literature
UnknownEffect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis.

Background

Guidelines exist for the surgical treatment of hip fracture, but the effect of early surgery on mortality and other outcomes that are important for patients remains unclear. We conducted a systematic review and meta-analysis to determine the effect of early surgery on the risk of ...
S-EPMC2952007 | biostudies-literature
UnknownEffects of remote ischemic preconditioning in high-risk patients undergoing cardiac surgery (Remote IMPACT): a randomized controlled trial.

Background

Remote ischemic preconditioning is a simple therapy that may reduce cardiac and kidney injury. We undertook a randomized controlled trial to evaluate the effect of this therapy on markers of heart and kidney injury after cardiac surgery.

Methods

Patients at high risk of dea...
S-EPMC4786386 | biostudies-literature
UnknownNeuraxial block and postoperative epidural analgesia: effects on outcomes in the POISE-2 trial†.

Background

We assessed associations between intraoperative neuraxial block and postoperative epidural analgesia, and a composite primary outcome of death or non-fatal myocardial infarction, at 30 days post-randomization in POISE-2 Trial subjects.

Methods

10 010 high-risk noncardiac su...
S-EPMC4681616 | biostudies-literature
UnknownPerioperative ischaemic brain injury and plasma neurofilament light: a secondary analysis of two prospective cohort studies.

Background

Ischaemic brain infarction can occur without acute neurological symptoms (covert strokes) or with symptoms (overt strokes), both associated with poor health outcomes. We conducted a pilot study of the incidence of preoperative and postoperative (intraoperative or postoperative) co...
S-EPMC9997085 | biostudies-literature
UnknownSmoking, Colchicine and Postoperative Outcomes in Thoracic Surgery: Post Hoc Analysis of the COP-AF Randomized Controlled Trial.

Background

To determine, among patients who underwent major noncardiac thoracic surgery, the association between smoking and perioperative atrial fibrillation (AF) and myocardial injury after noncardiac surgery (MINS), and whether the effect of colchicine use on these outcomes varied by smok...
S-EPMC12277807 | biostudies-literature
UnknownPrevention of peptic ulcers with esomeprazole in patients at risk of ulcer development treated with low-dose acetylsalicylic acid: a randomised, controlled trial (OBERON).

Objective

To determine whether once-daily esomeprazole 40 mg or 20 mg compared with placebo reduces the incidence of peptic ulcers over 26 weeks of treatment in patients taking low-dose acetylsalicylic acid (ASA) and who are at risk for ulcer development.

Design

Multinational, randomi...
S-EPMC3088470 | biostudies-literature
UnknownSex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data.

Aims

Data suggest that women have worse outcomes than men after coronary artery bypass grafting (CABG), but results have been inconsistent across studies. Due to the large differences in baseline characteristics between sexes, suboptimal risk adjustment due to low-quality data may be the rea...
S-EPMC8851663 | biostudies-literature
UnknownSafety and Efficacy of Tranexamic Acid in General Surgery.

Importance

Perioperative bleeding is common in general surgery. The POISE-3 (Perioperative Ischemic Evaluation-3) trial demonstrated efficacy of prophylactic tranexamic acid (TXA) compared with placebo in preventing major bleeding without increasing vascular outcomes in noncardiac surgery.
S-EPMC11904705 | biostudies-literature
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