Dgtp - OmicsDI

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UNIPROT ID/AC

O14556 (2)
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CHEBI ID

CHEBI:16335 (30)
CHEBI:15741 (29)
CHEBI:15428 (28)
CHEBI:15343 (18)
CHEBI:15377 (18)
CHEBI:15698 (18)
CHEBI:16526 (18)
CHEBI:16958 (18)
CHEBI:17256 (18)
CHEBI:18191 (18)
CHEBI:15380 (17)
CHEBI:15971 (17)
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CHEBI:16240 (17)
CHEBI:16349 (17)
CHEBI:16828 (17)
CHEBI:17115 (17)
CHEBI:17154 (17)
CHEBI:17172 (17)
CHEBI:17191 (17)
CHEBI:17203 (17)
CHEBI:17895 (17)
CHEBI:18012 (17)
CHEBI:29033 (17)
CHEBI:29101 (17)
CHEBI:37737 (17)
CHEBI:57692 (17)
CHEBI:14314 (16)
CHEBI:15033 (16)
CHEBI:15361 (16)

Metabolite Name

DGTP (21)
ADP (19)
ATP (18)
CDP (17)
IMP (16)
UDP (16)
UTP (16)
AMP (15)
CDP-choline (15)
CTP (15)
DCTP (15)
DGDP (15)
GDP (15)
GMP (15)
GTP (15)
UMP (15)
CMP (14)
DTDP (14)
NADH (14)
DCDP (13)
DGMP (13)
DTTP (13)
DUMP (13)
DUTP (13)
FAD (13)
Adenosine (12)
Allantoin (12)
Cytidine (12)
DAMP (12)
NADPH (12)

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Modelling Approach

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Lab affiliation

Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, UK. Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, UK. (1)
Mass Spectrometry Proteomics Science Technology Platform The Francis Crick Institute 1 Midland Road London United Kingdom (1)
Research Group on Neuromuscular and Mitochondrial Disorders, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Catalonia (1)

IsPrivate

False (22)

Submitter Keywords

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Classification

bacteria (11)
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Study type

Transcription profiling by array (1363)
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Identification of dGTP-interacting mitochondrial proteins by affinity purification and LC-ESI-MS/MS

Imbalanced mitochondrial dNTP pools are known players in the pathogenesis of multiple human diseases. However, we have shown that dGTP is largely overrepresented over the other dNTPs in mitochondria of mouse tissues and human cultured cells. Here, we have performed affinity purification studies and ...

ORGANISM(S): Mus musculus (Mouse)

2022-06-29 | PXD033900 | Pride

Transcriptome analysis of Escherichia coli during dGTP Starvation

Our laboratory has recently discovered that E. coli cells starved for the DNA precursor dGTP are killed efficiently (dGTP starvation) in a manner similar to that described for Thymineless Death (TLD). Conditions for specific dGTP starvation can be achieved by depriving an E. coli optA1 gpt strain o...

ORGANISM(S): Escherichia coli str. K-12 substr. MG1655

2016-04-06 | E-GEOD-80002 | biostudies-arrayexpress

Transcriptome analysis of Escherichia coli during dGTP Starvation

ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 Escherichia coli

2016-04-06 | GSE80002 | GEO

Suppressors of dGTP Starvation in Escherichia coli.

Not available

S-EPMC5446616 | biostudies-literature

Transcriptome Analysis of Escherichia coli during dGTP Starvation.

Not available

S-EPMC4959288 | biostudies-literature

Mechanism of allosteric activation of SAMHD1 by dGTP.