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ProteomicsEngineering Palmitoylated G-Quadruplex Aptamers to Target STAT3 and Overcome Therapeutic Resistance in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies owing to extensive therapeutic resistance and limited treatment options. Increasing evidence indicates that activation of the IL-6–JAK–STAT3 pathway represents a major adaptive survival mechanism that promotes resistance ...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-27 | PXD082487 | Pride
Aptamer  stat3  kras  g4 
ProteomicsRPA70 interactors in BJ and BJ RAS
Activation of oncogenes in healthy cells leads to a permanent cell cycle arrest termed oncogene-induced senescence (OIS) characterized by increased DNA damage and deep epigenetic resetting. Bypassing this premalignant state promotes tumorigenesis. Here, we show that cells entering OIS accumulate hig...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD060652 | Pride
Senescence Rpa70 Rnaseh1 R-loop 
ProteomicsHDAC4 interactors identified by MS/MS
Access to DNA is the first level of control in regulating gene transcription, a control that is also critical for maintaining DNA integrity. Cellular senescence is characterized by profound transcriptional rearrangements and accumulation of DNA lesions. Here, we discovered an epigenetic complex betw...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051316 | Pride
Hdac4  senescence  ms/ms 
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