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ProteomicsSUMO-2 activity is inhibited by non-covalent interactions with the Aβ peptide: an exploration of potential pathogenic mechanisms in Alzheimer’s Disease
SUMOylation is a post-translational modification involving the addition of SUMO isoforms to target proteins and plays a role in various biological processes, including neurodegenerative diseases and ocular pathologies. This study investigates the interaction between SUMO-2 and amyloid (Aβ) peptides,...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD066055 | Pride
Aβ Protein protein interactions Crosslinking ms Alzheimer’s disease Xl-ms Sumo-2 Cross-linking mass spectrometry 
ProteomicsNHS Carbamate Cross-Linkers Provide Complementary XL-MS Restraints via Preferential N-Terminal Targeting
Cross-linking mass spectrometry (XL-MS) has become a valuable tool for investigating the structural morphology and plasticity of proteins. Traditional cross-linkers contain two N-hydroxy succinimide (NHS) esters that mainly react with lysine residues. In this work, we optimized the in-solution react...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2026-03-30 | PXD069252 | Pride
Crosslinking ms Cross-linking ms Dsso carbamate Nhs carbamate cross-linkers N-terminal reactivity Xl-ms Cross-linking mass spectrometry Ms-cleavable cross-linkers 
ProteomicsStructural Assessment of the Full-Length Tumor Suppressor Protein p53 by Mass Spectrometry-Guided Computational Modeling
The tetrameric tumor suppressor p53 represents a great challenge for 3D structural analysis due to its high degree of intrinsic disorder (ca. 40%). We developed and applied an integrative structural biology approach combining complementary techniques of structural mass spectrometry (MS), namely cros...
ORGANISM(S): Escherichia coli 
2023-06-26 | PXD037030 | Pride
Computational modeling  cross-linking mass spectrometry  dna binding  intrinsically disordered proteins  tumor suppressor p53 
ProteomicsMolecular recognition of thyroglobulin by sortilin
Sortilin is a ubiquitous membrane receptor mediating protein trafficking along different cellular routes. In the thyroid gland, sortilin was proposed as a post-endocytic receptor of the thyroid hormone precursor, thyroglobulin (TG). It was reported that sortilin preferably shuttles iodinated TG to t...
ORGANISM(S): Homo sapiens (Human) 
2026-01-27 | PXD062462 | Pride
Thyroid Sortilin Cryo-em Thyroglobulin Cross-linking mass spectrometry Crosslinking mass spectrometry Crosslinking ms Trafficking Xl-ms Iodination Endocytosis 
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