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ProteomicsMus musculus primary CD4+ T cell di-glycine remnant and whole cell proteomics
It is known that ubiquitination is important for T cell receptor (TCR) signaling during T cell activation but the breadth of ubiquitination events triggered during TCR signaling is not completely understood. This dataset utilizes di-glycine remnant profiling combined with mass spectrometry to identi...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-09 | PXD012831 | Pride
Mus musculus primary cd4+ t cell di-glycine remnant and whole cell proteomics 
ProteomicsDi-glycine immunopurification proteomics of human skin
We performed profiling of Ubiquitin modifications in human skin which we compared to clinically relevant patient samples that model dysregulated ubiquitination, CYLD cutaneous syndrome (CCS) tumours. We utilised protein peptide di-glycine immuno-purification to enrich for ubiquitinated substrates, f...
ORGANISM(S): Homo sapiens (Human) 
2026-09-18 | PXD069159 | Pride
UnknownEnhanced uptake of potassium or glycine betaine or export of cyclic-di-AMP restores osmoresistance in a high cyclic-di-AMP Lactococcus lactis mutant.
Not available
S-EPMC6108528 | biostudies-literature
ProteomicsQuantitative proteomic analysis of SUMOylation in renal cortical collecting duct cells after aldosterone stimulation
SILAC was employed to investigate the effect of aldosterone stimulation on SUMOylation of cortical collecting duct (mpkCCD) cells.
ORGANISM(S): Mus musculus (Mouse) 
2019-10-07 | PXD013363 | Pride
Collecting duct Quantitative Renal Silac Kidney Sumoylation 
ProteomicsSUMOylation proteomic analysis of renal distal convoluted tubule cells
We profiled SUMO1 and SUMO2 modified proteins in distal convoluted tubule (mpkDCT) as a precursor to targeted approaches to assess SUMO function. SUMO levels in cells following heat shock and treatment with deSUMOylation inhibitors were assessed.
ORGANISM(S): Mus musculus (Mouse) 
2021-11-25 | PXD028507 | Pride
Distal convoluted tubule Renal Kidney Sumoylation 
ProteomicsSUMOylation proteomic analysis of renal cortical collecting duct cells
We profiled SUMO1 and SUMO2 modified proteins in cortical collecting duct (mpkCCD) as a precursor to targeted approaches to assess SUMO function. SUMO levels in cells following heat shock and treatment with deSUMOylation inhibitors were assessed.
ORGANISM(S): Mus musculus (Mouse) 
2019-10-07 | PXD013346 | Pride
Collecting duct Renal Kidney Sumoylation 
ProteomicsProteomic profiling of ubiquitylated proteins in urinary exosomes
Exosomes, derived from multivesicular bodies (MVBs), contain proteins and genetic materials from their cell of origin and are secreted from various cells types, including kidney epithelial cells. In general, it is thought that protein cargo is ubiquitylated, but that ubiquitin is cleaved by specific...
ORGANISM(S): Homo sapiens (Human) 
2016-02-22 | PXD002645 | Pride
Human Ubiquitylated proteins Urine Exosomes 
ProteomicsSystematic analysis of the ubiquitome in mouse testis
The ubiquitome was systematically investigated in mouse testis using di-glycine remnant antibodies by LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2021-06-03 | PXD025866 | Pride
Ubiquitination  testis  mouse 
ProteomicsSPATA2 links CYLD to the TNF-a receptor signaling complex and modulates the receptor signaling outcomes
TNF-a is a key regulator of innate immune and proinflammatory responses. However, the composition of the TNF-a receptor associated signaling complexes (TNF-RSC) and the architecture of the downstream signaling networks are incompletely understood. We employed quantitative mass spectrometry to demons...
ORGANISM(S): Homo sapiens (Human) 
2016-06-09 | PXD003627 | Pride
Necroptosis Tnf-alpha Nf-kappab Phosphorylation Ubiquitin 
ProteomicsUSP22 controls necroptosis by regulating receptor interacting protein kinase 3 ubiquitination
Dynamic control of ubiquitination by deubiquitinating enzymes is essential for almost all biological processes. Ubiquitin-specific peptidase 22 (USP22) is part of the SAGA complex and catalyzes the removal of monoubiquitination from histone H2B, thereby regulating gene transcription. However, novel ...
ORGANISM(S): Homo sapiens (Human) 
2021-05-03 | PXD020909 | Pride
Cancer/mlkl/posttranslational modifications/ripk1/ubiquitin hydrolase 
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