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UnknownQuantitative LFQ-DIA proteomics reveals FTH1-MCM5/WNT axis mediated osteoblastic dysfunction via ferroptosis drives diabetic osteoporosis.
Not available
S-EPMC12696055 | biostudies-literature
ProteomicsLFQ DIA to analyze the proteome of NPC mutant iNeurons with and without ferric ammonium citrate
Label-free quantification (LFQ) using data-independent acquisition (DIA) on the Orbitrap Astral was performed to analyze the proteome of iNeurons with NPC1 and NPC2 knocked out. The experiment includes the following time points of development: day 0, 4, 8, 16, and 22. All samples were cultured in re...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095985 | MassIVE
ProteomicsComparison of DIA and TMT based protein quantification in complex background
Label free quantification (LFQ) and isobaric labelling quantification (ILQ) are among the most popular protein quantification workflows in discovery proteomics. Here, we compared the TMT 10-plex workflow to label free single shot data-independent acquisition (DIA) method on a controlled sample set. ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-01-29 | MSV000084859 | MassIVE
ProteomicsDictyostelium DIA LFQ proteomics of vegetative and developmental growth
Dictyostelium discoideum behavior depends on nutrients. When sufficient food is present these amoebae exist in a unicellular state (vegetative growth), but upon starvation they aggregate into a multicellular organism (developmental growth). For proteomics 30 minutes and eight hour cultures of D. dis...
ORGANISM(S): Dictyostelium discoideum (Slime mold) 
2021-03-23 | PXD023404 | Pride
Dictyostelium discoideum  non-starved (vegetative)  starved (developmental)  dia hyper reaction monitoring  spectronaut  sulfur metabolism  reactive oxygen species 
ProteomicsQuantification of ATIs in Wheat by LC-MS/MS – LFQ DIA QTOF
A selection of ATIs was silenced in the common wheat cultivar Bobwhite and durum wheat cultivar Svevo by RNAi and gene editing, respectively, in order to reduce the amounts of ATIs. The controls and silenced lines were analyzed after digestion to peptides by LC-MS/MS with different approaches to eva...
ORGANISM(S): Triticum aestivum (Wheat) 
2022-10-13 | PXD034509 | Pride
Amylase/trypsin inhibitor  wheat  crsipr-cas9  rnai 
ProteomicsMulti-center study of E.coli colonies as a proof of concept for federated proteomics.
Quantitative mass spectrometry has transformed proteomics by allowing the simultaneous quantification of thousands of proteins. To boost statistical power, it is necessary to increase sample sizes by combining patient-derived data from various institutions. However, this practice raises significant ...
ORGANISM(S): Escherichia coli 
2025-04-29 | PXD053812 | Pride
E.coli Dia-lfq 
ProteomicsDeep and fast label-free Dynamic Organellar Mapping - DIA datasets
The Dynamic Organellar Maps (DOMs) approach combines cell fractionation and shotgun-proteomics for global profiling analysis of protein subcellular localization. Here, we have drastically enhanced the performance of DOMs through data-independent acquisition (DIA) mass spectrometry (MS). DIA-DOMs ach...
ORGANISM(S): Homo sapiens (Human) 
2023-08-25 | PXD034971 | Pride
Dynamic organellar maps Dia Data quality control Data-independent acquisition mass spectrometry Spatial proteomics Profiling analysis 
UnknownProteome alterations in the aqueous humor reflect structural and functional phenotypes in patients with advanced normal-tension glaucoma.
Not available
S-EPMC8786875 | biostudies-literature
UnknownA High-Sensitivity Low-Nanoflow LC-MS Configuration for High-Throughput Sample-Limited Proteomics.
Not available
S-EPMC10753523 | biostudies-literature
ProteomicsDeciphering the central role of TMOD2 in colorectal cancer progression and metastasis
Tropomodulin-2 (TMOD2) was previously identified as upregulated in the nuclear compartment of highly metastatic KM12SM colorectal cancer (CRC) cells. Here, we aimed to investigate its role using multiple CRC cell lines and patient-derived samples through functional proteomics, bioinformatics, and in...
ORGANISM(S): Homo sapiens (Human) 
2025-09-14 | PXD057708 | Pride
Colorectal cancer  tmod2  proteomics  lfq  protein-protein interactions Cancer metastasis 
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