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MetabolomicsFunctional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina

Pericyte loss is an early and critical event in the pathogenesis of diabetic retinopathy (DR), yet the molecular mechanisms underlying pericyte dysfunction remain incompletely understood. Using single-cell RNA sequencing, we generated a retinal cellular overview comprising 18,926 cells from...

2026-03-27 | MTBLS13544 | MetaboLights
ProteomicsProteomics in exploring the endothelial dysfunction mechanism induced by serum exosomes from diabetic retinopathy and diabetic nephropathy patients
In this study, we used human glomerular endothelial cells (HGECs) as cells model, proteomics TMT-based LC-MS/MS was employed to discover the underlying mechanisms of endothelial dysfunction caused by SExos from diabetic retinopathy and nephropathy patients.
ORGANISM(S): Homo Sapiens 
2021-12-29 | PXD030660 |
MetabolomicsFunctional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina
Pericyte loss is an early and critical event in the pathogenesis of diabetic retinopathy (DR), yet the molecular mechanisms underlying pericyte dysfunction remain incompletely understood. Using single-cell RNA sequencing, we generated a retinal cellular overview comprising 37,982 cells from diabetic...
2026-03-30 | MTBLS14184 | MetaboLights
ProteomicsExtracellular vesicles of human diabetic retinopathy retinal tissue and urine of diabetic retinopathy patients analyzed using mass spectrometry
Diabetic Retinopathy (DR) is a potentially blinding retinal disorder which develops through the pathogenesis of diabetes. Extracellular Vesicles (EVs) provide a novel biomarker for pre-symptomatic disease diagnosis and prognosis. Proteomic analysis was performed on explanted DR retinal tissue, DR r...
ORGANISM(S): Homo sapiens (Human) 
2022-12-31 | PXD034626 | Pride
Lc-ms/ms Exosome Diabetic retinopathy 
ProteomicsIdentification and Validation of microparticle proteins as biomarkers for diabetic retinopathy
Diabetic retinopathy (DR) is a microvascular complication that develops in diabetic individuals. There are currently no methods to detect the onset or progression of DR. Biomarkers can help identify the subset of diabetics who are at high risk of developing DR or those DR patients with a high proba...
ORGANISM(S): Homo sapiens (Human) 
2025-01-17 | PXD036079 | Pride
Diabetic retinopathy Microparticles Serum Biomarkers 
ProteomicsPutative tear fluid biomarkers of diabetic retinopathy
Identification of tear fluid biomarkers may offer a non-invasive strategy for detecting diabetic patients with increased risk of developing diabetic retinopathy (DR) or increased disease progression, thus helping both improving diagnostic accuracy and understanding the pathophysiology of the disease...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD033101 | Pride
Human Lc-msms Type 2 diabetes Proliferative diabetic retinopathy Nonproliferative diabetic retinopathy Tear fluid 
ProteomicsSystem-wide vitreous proteome dissection reveals impaired sheddase activity in diabetic retinopathy
Diabetic retinopathy (DR) is a major complication of diabetes mellitus causing significant vision loss. Despite the success of anti-VEGF therapy as an effective therapy, many DR patients do not respond well to the treatment, emphasizing the involvement of other molecular players. To unveil these, we...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD036033 | Pride
Vitreous humor/diabetic retinopathy/ectodomain shedding/sheddase 
ProteomicsPRM-Based Quantitative Proteome Profiling of Aqueous Humor of Diabetic Retinopathy
Diabetic retinopathy (DR) is a leading cause of irreversible vision impairment and blindness. To explore the dynamics of aqueous humor (AH) protein profiles during four stages from non-diabetic individuals to proliferative diabetic retinopathy patients, especially to improve our understanding of pat...
ORGANISM(S): Homo Sapiens 
2024-07-04 | PXD053634 |
ProteomicsProteomic Analysis of Aqueous Humor Identified Clinically Relevant Molecular Targets for Neovascular Complications in Diabetic Retinopathy
Diabetic retinopathy (DR) is a leading cause of blindness in adults under 40 in the developed world, with a significant proportion progressing to vision-threatening stages like proliferative diabetic retinopathy (PDR) and neovascular glaucoma (NVG). This study aims to explore the molecular mechanism...
ORGANISM(S): Homo sapiens (Human) 
2025-05-01 | PXD058481 | Pride
Diabetic retinopathy Aqueous humor Proteomics 
ProteomicsComparative Proteomic Analysis of Human Vitreous in Rhegmatogenous Retinal Detachment and Diabetic Retinopathy
The vitreous humor can provide important information about physiological and pathophysiological processes within the eye, particularly concerning the retina. Despite the widespread prevalence of various vitreoretinal diseases, that can ultimately lead to blindness, there is not a clear understanding...
ORGANISM(S): Homo sapiens (Human) 
2025-02-24 | PXD050611 | Pride
Diabetic retinopathy Human vitreous humor Rhegmatogenous retinal detachment 
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