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TranscriptomicsMycobacterial cells have dual nickel-cobalt sensors: sequence-relationships and metal-sites of metal-responsive repressors are not congruent.
A novel ArsR-SmtB family transcriptional repressor, KmtR, has been characterised from mycobacteria. Mutants of M. tuberculosis lacking kmtR show elevated expression of Rv2025c encoding a deduced CDF-family metal-exporter. KmtR-dependent repression of the cdf and kmtR operator-promoters was alleviate...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-17 | E-BUGS-49 | biostudies-arrayexpress
TranscriptomicsAdaptation of E. histolytica to long term glucose starvation
We have performed a DNA microarray analysis of gene expression in trophozoites which were adapted to grow in a media depleted from glucose for one month and on glucose-starved trophozoites which were recovered with the addition of glucose.
ORGANISM(S): Entamoeba histolytica 
2012-07-01 | E-MTAB-1187 | biostudies-arrayexpress
TranscriptomicsHepatic Gene Expression in Rainbow Trout (Oncorhynchus mykiss) Exposed to Different Hydrocarbon Mixtures
Traditional biomarkers for hydrocarbon exposure are not induced by all petroleum substances. The objective of this study was to determine if exposure to a crude oil and different refined oils would generate a common hydrocarbon-specific response in gene expression profiles that could be used as gene...
ORGANISM(S): Oncorhynchus mykiss 
2010-05-18 | E-GEOD-19483 | biostudies-arrayexpress
TranscriptomicsTemporal patterns in the transcriptomic response of rainbow trout, Oncorhynchus mykiss, to crude oil
Time is often not characterized as a variable in ecotoxicogenomic studies. In this study, the temporal kinetics in gene expression were determined during exposure to crude oil and a subsequent recovery period. Juvenile rainbow trout, Oncorhynchus mykiss, were exposed for 96 hours to the water accom...
ORGANISM(S): Oncorhynchus mykiss 
2010-05-18 | E-GEOD-19489 | biostudies-arrayexpress
TranscriptomicsNormal and shortened photoperiods in liver, ovary, and pituitarty
This study compared changes in gene expression in an oviparous female fish, the rainbow trout (Oncorhynchus mykiss), under two different photoperiod treatments, a natural photoperiod (NP) and a shortened photoperiod (SP; 60% of NP). Gene expression in the liver, ovary and pituitary were measured at ...
ORGANISM(S): Oncorhynchus mykiss 
2010-05-18 | E-GEOD-19478 | biostudies-arrayexpress
GenomicsMyc and SAGA Rewire an Alternative Splicing Network During Early Somatic Cell Reprogramming
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-67719 | biostudies-arrayexpress
TranscriptomicsUsing ChIP-chip technology to reveal common principles of transcriptional repression in normal and cancer cells
We compared 12 different cell populations, including embryonic stem cells before and during differentiation into embryoid bodies as well as various types of normal and tumor cells to determine if pluripotent vs. differentiated cell types use different mechanisms to establish their transcriptome. We ...
ORGANISM(S): Mus musculus 
2008-03-31 | E-GEOD-10504 | biostudies-arrayexpress
GenomicsNational Cancer Institute (NCI) TARGET: Therapeutically Applicable Research to Generate Effective Treatments

The Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative seeks to accelerate research in novel marker and drug development, along with understanding the molecular basis of pediatric malignancy, through identification of genomic changes associated with the follo...

phs000218.v5.p1 | EGA
TranscriptomicsAn in vivo screen identifies compounds that disrupt heterochromatin integrity
Heterochromatin plays a key role in gene repression, maintaining genome integrity and chromosome segregation. Fission yeast, Schizosaccharomyces pombe, utilizes conserved components to direct heterochromatin formation using siRNA generated by RNA interference (RNAi) to guide a histone H3 lysine 9 me...
ORGANISM(S): Schizosaccharomyces pombe 
2014-12-17 | E-GEOD-57207 | biostudies-arrayexpress
TranscriptomicsRNAPolII ChIP to find differences between third instar salivary glands of WT and SuUR
ChIP was performed to identify regions of gDNA bound by RNA polymerase II in third instar salivary glands of Drosophila WT and SuUR mutants. This demonstrated that RNAPolII does not localize to regions that are under-replicated in SuUR mutant third instar salivary glands. Comparison of RNAPolII ChI...
ORGANISM(S): Drosophila melanogaster 
2011-10-17 | E-GEOD-31896 | biostudies-arrayexpress
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