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ProteomicsCentral nervous system involvement of acute lymphoblastic leukemia depends on mRNA translation and complement component 3
Central nervous system (CNS) dissemination of B-precursor acute lymphoblastic leukemia (B-ALL) has a poor prognosis and remains a therapeutic challenge with few recent advances in therapy. Leptomeningeal disease is particularly common in the high risk subgroup of KMT2A-rearranged B-ALL (KMT2A-r B-AL...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD022411 | Pride
Lc-ms Leukemia Lfq 
ProteomicsmiR-125a Confers Multi-Lineage Long-Term Repopulating Stem Cell Activity to Murine and Human Hematopoietic Progenitors
Umbilical cord blood (CB) is a non-invasive, convenient and broadly used source of hematopoietic stem cells (HSCs) for allogeneic stem cell transplantation. However, limiting numbers of HSCs remain a major constraint for its clinical application. One feasible option would be to expand HSCs to improv...
ORGANISM(S): Homo sapiens (Human) 
2017-01-11 | PXD003931 | Pride
Hematopoiesis Stem cell proteomics Microrna Low-cell input 
ProteomicsmiR-126 Governs Human Leukemia Stem Cell Quiescence and Therapeutic Resistance
In acute myeloid leukemia (AML), leukemia stem cells (LSC) play a central role in disease progression and recurrence due to their intrinsic capacity for self-renewal and chemotherapy resistance. Whereas epigenetic mechanisms balance normal blood stem cell self-renewal and fate decisions, mutation an...
ORGANISM(S): Homo sapiens (Human) 
2016-03-31 | PXD001994 | Pride
Aml Global proteomics Scx Stem cells Mir126 
ProteomicsGlobal Identification of the miR-130a targetome in human HSPC Reveals a Novel Role for TBL1XR1 in Hematopoietic Stem Cell Self-Renewal and t(8;21) AML
Gene expression profiling and proteome analysis of normal and malignant hematopoietic stem cells have firmly established the existence of shared core stemness properties. However, the discordance between mRNA and protein signatures underscores an important role for post-transcriptional regulation by...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD027331 | Pride
Lc-ms Acute myeloid leukemia Mirna Hematopoiesis 
TranscriptomicsThe transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment.
Here we tracked transcriptome changes over ten human hematopoietic stem and early progenitor populations, defining the transcriptional dynamics underlying the first steps of commitment. Most of the transcriptional programs observed extended beyond lineage boundaries. In particular, multi-lymphoid pr...
ORGANISM(S): Homo sapiens 
2013-05-26 | E-GEOD-42414 | biostudies-arrayexpress
TranscriptomicsGene expression data from sorted and unsorted primary human acute myeloid leukemia (AML) samples
Experiments using xenografts show that some solid tumours and leukemias are organized as cellular hierarchies sustained by cancer stem cells (CSC). Despite promise, the relevance of the CSC model to human disease remains uncertain. Here we show that acute myeloid leukemia (AML) follows a CSC model b...
ORGANISM(S): Homo sapiens 
2011-08-27 | E-GEOD-30375 | biostudies-arrayexpress
TranscriptomicsGene expression data from sorted primary human cord blood samples
Experiments using xenografts show that some solid tumours and leukemias are organized as cellular hierarchies sustained by cancer stem cells (CSC). Despite promise, the relevance of the CSC model to human disease remains uncertain. Here we show that acute myeloid leukemia (AML) follows a CSC model b...
ORGANISM(S): Homo sapiens 
2011-08-27 | E-GEOD-30376 | biostudies-arrayexpress
TranscriptomicsAttenuation of miR-126 activity expands HSC in vivo without exhaustion
Life-long blood cell production is governed through the poorly understood integration of cell-intrinsic and -extrinsic control of hematopoietic stem cell (HSC) quiescence and activation. MicroRNAs (miRNAs) coordinately regulate multiple targets within signaling networks making them attractive candid...
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-40458 | biostudies-arrayexpress
GenomicsInhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [ChIP-Seq]
All-trans-retinoic acid (ATRA) has been successfully used in therapy of acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukemia (AML) but the response of non-APL AML cases to ATRA-based treatment has been poor. Here we show that, via epigenetic reprogramming,...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-34725 | biostudies-arrayexpress
TranscriptomicsInhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [Illumina HumanHT-12 gene expression array]
All-trans-retinoic acid (ATRA) has been successfully used in therapy of acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukemia (AML) but the response of non-APL AML cases to ATRA-based treatment has been poor. Here we show that, via epigenetic reprogramming,...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-34672 | biostudies-arrayexpress
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