Sort   by:  
 Page size 
MetabolomicsPrediction of complex phenotypes using the Drosophila melanogaster metabolome
Understanding the genotype-phenotype map and how variation at different levels of biological organization is associated are central topics in modern biology. Fast developments in sequencing technologies and other molecular omic tools enable researchers to obtain detailed information on variation at ...
2021-08-05 | MTBLS2060 | MetaboLights
MetabolomicsA novel strategy for mining and identification of acylcarnitines using data-independent-acquisition (DIA) based retention time prediction modeling and pseudo-characteristic fragmentation ions matching
It is a challenging work to screen, identify, and quantify acylcarnitines in complex biological samples. A method, based on the retention time (RT) prediction and data-independent acquisition strategies, was proposed for the large-scale identification of acylcarnitines using liquid chromatography co...
2021-10-06 | MTBLS1932 | MetaboLights
MetabolomicsPersistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease

OBJECTIVES: Celiac disease (CD) is a chronic enteropathy characterized by an autoimmune reaction in the small intestine of genetically susceptible individuals. The underlying causes of autoimmune reaction and its effect on host metabolism remain largely unknown. Herein, we apply ...

2020-01-22 | MTBLS729 | MetaboLights
MetabolomicsClostridioides difficile-commensal interactions are impacted by diet more than differences between strain

The purpose of this study was to investigate how C. difficile metabolism differs between strains as a function of diet. We used three C. difficile strains (R20291, Cd4, and Cd10). Each strain was grown in three different media conditions designed to mimic different diet conditio...

2026-09-18 | MTBLS15045 | MetaboLights
ProteomicsMetaproteomics of stool samples collected from free-eating individual for diet prediction
Assessment of diet currently relies on self-reporting, such as food logs, 24 hour recalls and food frequency questionnaires. Self-reporting of diet is inaccurate due to memory lapses, lying and biased language. A molecular-based approach to assess diet would allow accurate reporting of diet for rese...
ORGANISM(S): Homo sapiens (Human) Bacteria Fungi Viridiplantae Metazoa (Animals) 
2024-12-23 | PXD029334 | Pride
1d-lc Metaproteome Microbiome Diet Diet prediction Metaproteomics 
ProteomicsMetaproteomics of human stool samples for diet assessment
Assessment of diet currently relies on self-reporting, such as food logs, 24 hour recalls and food frequency questionnaires. Self-reporting of diet is inaccurate due to memory lapses, lying and biased language. A molecular-based approach to assess diet would allow accurate reporting of diet for rese...
ORGANISM(S): Homo sapiens (Human) Bacteria Fungi Viridiplantae Metazoa (Animals) 
2024-12-23 | PXD030004 | Pride
1d-lc Metaproteome Microbiome Diet Diet prediction Metaproteomics 
ProteomicsThe cyclin dependent kinase inhibitor Roscovitine reverses diet-induced metabolic disruption in obese mice
We show that roscovitine; a cyclin-dependent kinases inhibitor; given to mice during the last six weeks of a 19-week high fat diet, reduced weight gain and prevented accompanying insulin resistance, hepatic steatosis, visceral adipose tissue (eWAT) inflammation and fibrosis. It also restored insulin...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD027981 | Pride
Proteomics Obesity Adipose mitochondria Therapy Roscovitine 
TranscriptomicsMiR-155 is protective of dietary non-alcoholic hepatosteatosis
We used microarrays to characterize the gene expression changes in liver caused by high fat diet feeding to C57BL/6 WT and miR-155-/- mice. Livers were collected from male mice at 24 weeks of age for RNA extraction and hybridization on Affymetrix mouse gene 1.0 ST array . We extracted RNA from 3 ani...
ORGANISM(S): Mus musculus 
2013-11-04 | E-MEXP-3932 | biostudies-arrayexpress
MetabolomicsSex-dependent metabolic remodeling of kidneys revealed by arteriovenous metabolomics

Sex is a fundamental biological variable important in biomedical research, drug development, clinical trials, and prevention approaches. Among many organs, kidneys are known to exhibit remarkable structural, histological, and pathological differences between sexes. However, whether and how kidney...

2026-03-04 | MTBLS13977 | MetaboLights
MetabolomicsLipid Droplet Inhibitors for Disrupting Lipid Accumulation in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Excessive lipid droplet accumulation in hepatocytes drives the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), often leading to inflammation and fibrosis. As obesity and metabolic syndrome rise, MASLD has become a global concern, spurring research into effective trea...
2025-07-17 | MTBLS12359 | MetaboLights
Sort   by:  
 Page size