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ProteomicsMulti-omics of colon tumor progression organoids reveals putative mediators of colorectal cancer metastasis
The development of metastasis severely reduces the life expectancy of patients with colorectal cancer (CRC). Loss of SMAD4 is a key event in late-stage CRC resulting in the progression to metastatic CRC in 10-30% of the cases. However, the biological processes and underlying molecular mechanisms tha...
ORGANISM(S): Homo sapiens (Human) 
2022-12-11 | PXD036441 | Pride
Whole-cell proteomics Secretomics Colon cancer Smad4 Metastasis 
ProteomicsTHRONCAT: Efficient metabolic labelling of newly synthesized proteins using a bioorthogonal threonine analogue
Profiling the nascent cellular proteome and capturing early proteomic changes in response to external stimuli provides valuable insight into cellular physiology. Existing metabolic protein labelling approaches based on bioorthogonal methionine- or puromycin analogueues allow for the selective visual...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD032368 | Pride
Throncat Boncat Lc-ms/ms 
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