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ProteomicsMitochondrial stress in GLA mutants Zebrafish is independent of globotriaosylceramide accumulation
Fabry disease (FD) is a hereditary lysosomal storage disorder caused by mutations in GLA gene resulting in reduction or lack of α-galactosidase A activity. In humans, enzymatic deficiency leads to accumulation of globotriaosylceramide (Gb3) and other glycosphingolipids in lysosomes. Current therapie...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2023-10-24 | PXD035409 | Pride
Alpha-galactosidase a/ fabry disease/ lysosome/ mitochondrial activity/ proteomic approach 
TranscriptomicsDistinctive metabolic remodeling in TYMP deficiency beyond mitochondrial dysfunction
Purpose: Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), a rare mitochondrial encephalomyopathy subtype, is caused by mutations of thymidine phosphorylase (TYMP). As a metabolic enzyme localized in the cytoplasm, the biological processes disturbed by TYMP functional defect are suppose...
ORGANISM(S): Homo sapiens 
2025-03-01 | GSE222921 | GEO
GenomicsDistinctive metabolic remodeling in TYMP deficiency beyond mitochondrial dysfunction
Distinctive metabolic remodeling in TYMP deficiency beyond mitochondrial dysfunction
PRJNA924032 | ENA
UnknownMitochondrial Peroxiredoxin 3 Is Rapidly Oxidized and Hyperoxidized by Fatty Acid Hydroperoxides.
Not available
S-EPMC9952270 | biostudies-literature
ProteomicsInherited mitochondrial dysfunction impacts corneal innervation fibre identity, fonctionnality and regenerative potential
The cornea is the transparent tissue covering the anterior part of the eye. Its main roles are to convey the light toward the retina, and to act as a protective barrier against infection or injury for the eye. The transparency of the cornea is a crucial component of its functionality and is the resu...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-25 | PXD052337 | Pride
Epithelium Mitochondria Transcriptomic Opa1 Innervation Proteomic Cornea Tear film 
UnknownNisin lantibiotic prevents NAFLD liver steatosis and mitochondrial oxidative stress following periodontal disease by abrogating oral, gut and liver dysbiosis.
Not available
S-EPMC10794237 | biostudies-literature
GenomicsMus musculus
The metabolic sensor LKB1 regulates ILC3 homeostasis and mitochondrial function
PRJNA1132965 | ENA
ProteomicsAntifungal Synergy: Mechanistic Insights into the R-1-R Peptide and Bidens pilosa Extract as Potent Therapeutics against Candida spp. through Proteomics
Previous work has reported that the peptide derived from LfcinB, R-1-R exhibited anti-Candida activity, which is enhanced when combined with an extract from the Bidens pilosa plant. However, the mechanism of action has not been studied until now. In the current study, an approach to the mechanism of...
ORGANISM(S): Candida albicans (Yeast) 
2024-10-17 | PXD053558 | Pride
Bovine lactoferricin peptides  bidens pilosa  candida albicans Proteomics Antifungal resistance. Disfunction mitochondrial Ros 
UnknownWhole transcriptome approach to evaluate the effect of aluminium hydroxide in ovine encephalon.
Not available
S-EPMC7498608 | biostudies-literature
UnknownOff-Target Effect of Lovastatin Disrupts Dietary Lipid Uptake and Dissemination through Pro-Drug Inhibition of the Mesenteric Lymphatic Smooth Muscle Cell Contractile Apparatus.
Not available
S-EPMC8584239 | biostudies-literature
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