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TranscriptomicsTranscription profiling of human control (hMSC-TERT) vs Dlk overexpressing cells (hMSC-Dlk1) to analyse Dlk1-mediated signaling pathways during hMSC differentiation
We aimed in this study to identify the differentially regulated genes by Dlk1 in hMSC cells using microarray technology in order to gain a better understanding of Dlk1-mediated signaling pathways during hMSC differentiation. Both control (hMSC-TERT)(not expressing Dlk1) and Dlk1 overexpressing cells...
ORGANISM(S): Homo sapiens 
2006-02-10 | E-MEXP-560 | biostudies-arrayexpress
TranscriptomicsDLK1 Is a Novel Regulator of Bone Mass That Mediates Estrogen-Deficiency Induced Bone Loss in Mice
DLK1/FA-1 (delta-like 1/fetal antigen-1) is a transmembrane protein belonging to Notch/Delta family that acts as a membrane-associated or a soluble protein to regulate regeneration of a number of adult tissues. Here, we examined the role of DLK1/FA-1 in bone biology using osteoblast-specific-Dlk1 ov...
ORGANISM(S): Mus musculus 
2010-10-15 | E-GEOD-22113 | biostudies-arrayexpress
ProteomicsA proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma
Cancer immunotherapies have produced remarkable results in B-cell malignancies; however, optimal cell surface targets for many solid cancers remain elusive. Here, we present an integrative proteomic, transcriptomic, and epigenomic analysis of tumor specimens along with normal tissues to identify bio...
ORGANISM(S): Homo sapiens (Human) 
2024-10-23 | PXD047474 | Pride
Neuroblastoma Antibody-drug conjugate Mass spectrometry Immunotherapy Cancer Dlk1 Surfaceome 
GenomicsSingle cell RNAseq data from Dlk1+ and Dlk1- aged murine hematopoietic stem cells
Single cell RNAseq data from Dlk1+ and Dlk1- aged murine hematopoietic stem cells
PRJNA770249 | ENA
GenomicsTranscriptome analysis of CMK cells with DLK1 knockout
Transcriptome analysis of CMK cells with DLK1 knockout
PRJNA1328741 | ENA
TranscriptomicsExpression data from human embryonic stem cells(hESCs)
To detect the effect of early culture on hESCs, almost all initial-passaged hESCs have normal expression of DLK1-DIO3 gene cluster, the low-passaged hESCs lost the expression of DLK1-DIO3 gene cluster. hESCs were extracted for RNA with TriZOL and hybridization on Affymetrix arrays
ORGANISM(S): Homo sapiens 
2014-06-30 | E-GEOD-38662 | biostudies-arrayexpress
UnknownTRIM28 Regulates Dlk1 Expression in Adipogenesis.
Not available
S-EPMC7582669 | biostudies-literature
UnknownNiche-derived soluble DLK1 promotes glioma growth.
Not available
S-EPMC7587507 | biostudies-literature
TranscriptomicsSingle cell RNAseq data from Dlk1+ and Dlk1- aged murine hematopoietic stem cells
Quantification of gene expression noise on young versus aged bone marrow HSCs at single-cell resolution revealed Dlk1 increases both noise and expression levels upon aging. Dlk1, encoding a cell surface non-canonical Notch ligand, is partially expressed in the LT-HSC compartment, without generating ...
ORGANISM(S): Mus musculus 
2023-05-13 | GSE185637 | GEO
UnknownMolecular mechanism of Activin receptor inhibition by DLK1.
Not available
S-EPMC12216052 | biostudies-literature
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