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ProteomicsDDA1, a novel factor in transcription-coupled repair, modulates CRL4CSA dynamics at DNA damage-stalled RNA polymerase II
Transcription–blocking lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to counteract aging. TC-NER is initiated by the physical stalling o...
ORGANISM(S): Homo sapiens (Human) 
2024-05-31 | PXD045415 | Pride
Dna damage-stalled rna polymerase ii Transcription-coupled repair Crl4csa dynamics Dda1 
UnknownDegradation of DNA damage-independently stalled RNA polymerase II is independent of the E3 ligase Elc1.
Not available
S-EPMC4176355 | biostudies-literature
UnknownThe cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.
Not available
S-EPMC7192910 | biostudies-literature
ProteomicsDDA1, a novel factor in transcription-coupled repair, modulates CRL4CSA dynamics at DNA damage-stalled RNA polymerase II
Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to counteract aging. TC-NER is initiated by the stalling of RNA...
ORGANISM(S): Homo sapiens (Human) 
2024-05-02 | PXD051638 | Pride
Crl4csa Rna polymerase ii Dna damage Dda1 Transcription-coupled repair 
ProteomicsUV-specific and -indepent interactors
The response to DNA damage-stalled RNA polymerase II (RNAPIIo) involves the assembly of the transcription-coupled repair (TCR) complex on actively transcribed strands. The function of the TCR proteins CSB, CSA and UVSSA and the manner in which the core DNA repair complex, including transcription fac...
ORGANISM(S): Homo sapiens (Human) 
2020-04-14 | PXD013572 | Pride
Tc-ner 
ProteomicsGFP-CSB and GFP-UVSSA Domain-specific interactors
The response to DNA damage-stalled RNA polymerase II (RNAPIIo) involves the assembly of the transcription-coupled repair (TCR) complex on actively transcribed strands. The function of the TCR proteins CSB, CSA and UVSSA and the manner in which the core DNA repair complex, including transcription fac...
ORGANISM(S): Homo sapiens (Human) 
2020-04-14 | PXD017329 | Pride
Uvssa Csb Tc-ner 
UnknownA SUMO-dependent pathway controls elongating RNA Polymerase II upon UV-induced damage.
Not available
S-EPMC6884465 | biostudies-literature
ProteomicsStructural basis of human transcription-DNA repair coupling
Transcription-coupled DNA repair (TCR) efficiently removes bulky DNA lesions from transcribed parts of the genome and constitutes a major defence against DNA damage by UV irradiation. TCR begins when RNA polymerase II (Pol II) stalls at a DNA lesion and recruits the Cockayne syndrome protein CsB, th...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2022-02-17 | PXD025328 | Pride
Protein-protein crosslinking Transcription-dna repair Ubiquitination analysis 
GenomicsELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation
ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation
PRJNA630062 | ENA
UnknownDifferential processing of RNA polymerase II at DNA damage correlates with transcription-coupled repair syndrome severity.
Not available
S-EPMC11381366 | biostudies-literature
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