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ProteomicsAnti-DnaA antibodies specificity validation by mass spectrometry
The ubiquitous protein DnaA is a chromosomal DNA replication initiator and transcription factor. It binds to 9-bp DNA sites called "DnaA-boxes" that are localized within the replication origin (oriC) and throughout chromosomal DNA, usually in the proximity of the promoter regions. During stress, bac...
ORGANISM(S): Escherichia coli 
2026-03-02 | PXD061973 | Pride
Sample specificity Escherichia coli Chip-seq Dnaa Rabbit antibodies 
ProteomicsThe Escherichia coli replication initiator DnaA is titrated on the chromosome
DNA replication initiation is orchestrated in bacteria by the replication initiator DnaA. Two models for regulation of DnaA activity in Escherichia coli have been proposed: the switch between an active and inactive form and the titration of DnaA on the chromosome. Although proposed decades ago, expe...
ORGANISM(S): Escherichia coli 
2025-07-28 | PXD064841 | Pride
Titration model Single-particle tracking photoactivatable localisation microscopy Switch model Dnaa protein Oric Dnaa boxes chromosome binding Data Replication initiator 
UnknownMutations of DnaA-boxes in the oriR region increase replication frequency of the MiniR1-1 plasmid.
Not available
S-EPMC5883639 | biostudies-literature
UnknownCluster of DnaA boxes involved in regulation of Streptomyces chromosome replication: from in silico to in vivo studies.
Not available
S-EPMC1595370 | biostudies-literature
ProteomicsBacillus subtilis remains translationally active after CRISPRi-mediated replication initiation arrest
Initiation of bacterial DNA replication takes place at the origin of replication (oriC), a region characterized by the presence of multiple DnaA boxes that serve as the binding sites for the master initiator protein DnaA. The absence or failure of DNA replication can result in bacterial cell growth ...
ORGANISM(S): Bacillus subtilis PY79 
2024-03-26 | PXD036876 | Pride
Bacillus subtilis Dnaa boxes Oric Replication Crispri 
GenomicsChIP-seq experiment: DnaA binding to E. coli chromosome before stress, during stress, and stress recovery
The ubiquitous protein DnaA is a chromosomal DNA replication initiator and transcription factor. It binds to 9-bp DNA sites called \"DnaA-boxes\" that are localized within the replication origin (oriC) and throughout chromosomal DNA, usually in the proximity of the promoter regions. During stress, b...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2026-03-13 | E-MTAB-14964 | biostudies-arrayexpress
ProteomicsEstablishment of titration-based control of DNA replication in Escherichia coli
Escherichia coli couples the initiation of DNA replication with cell size by modulating the activity of the replication initiator protein DnaA. The activity of DnaA is regulated both by its interconversion between an active and inactive form and by its titration on chromosomal binding sites. Whereas...
ORGANISM(S): Escherichia coli 
2026-09-10 | PXD075568 | Pride
Hyper-replicative stress Dnaa-atp/dnaa-adp switch Replication forks Dnaa boxes Dnaa Titration-based control of dna replication 
UnknownA novel mode of DnaA-DnaA interaction promotes ADP dissociation for reactivation of replication initiation activity.
Not available
S-EPMC6868365 | biostudies-literature
UnknownStructural basis of replication origin recognition by the DnaA protein.
Not available
S-EPMC153737 | biostudies-literature
UnknownPutative Cooperative ATP-DnaA Binding to Double-Stranded DnaA Box and Single-Stranded DnaA-Trio Motif upon Helicobacter pylori Replication Initiation Complex Assembly.
Not available
S-EPMC8235120 | biostudies-literature
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