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ProteomicsIdentification of protein interactors of SPAG1 in human airway epithelia
Dysfunctional motile cilia result in primary ciliary dyskinesia (PCD), a genetically heterogeneous disorder characterized by chronic oto-sino-pulmonary disease, infertility, and laterality defects. Mutations in dynein axonemal assembly factors (DNAAF), that facilitate the assembly of dynein arms in ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-20 | PXD032349 | Pride
Cilia Affinity purification-mass spectrometry Spag1 
UnknownGene dosage of independent dynein arm motor preassembly factors influences cilia assembly in Chlamydomonas reinhardtii.
Not available
S-EPMC11020789 | biostudies-literature
UnknownA null allele of Dnaaf2 displays embryonic lethality and mimics human ciliary dyskinesia.
Not available
S-EPMC6688062 | biostudies-literature
UnknownCiliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP.
Not available
S-EPMC6028525 | biostudies-literature
UnknownFBB18 participates in preassembly of almost all axonemal dyneins independent of R2TP complex.
Not available
S-EPMC9455862 | biostudies-literature
UnknownA liquid-like organelle at the root of motile ciliopathy.
Not available
S-EPMC6349401 | biostudies-literature
UnknownChlamydomonas WDR92 in association with R2TP-like complex and multiple DNAAFs to regulate ciliary dynein preassembly.
Not available
S-EPMC6821370 | biostudies-literature
UnknownThe role of SPAG1 in the assembly of axonemal dyneins in human airway epithelia.
Not available
S-EPMC8995097 | biostudies-literature
UnknownCoding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes.
Not available
S-EPMC7672046 | biostudies-literature
ProteomicsDNAAF9 interactome from human airway epithelial cells
Biogenesis of motile cilia in multiciliated cells (MCCs) is coupled to large-scale biosynthesis of force generating dynein motors. Shulin inhibits pre-assembled ODA (outer dynein arm) motors by packaging them into a closed conformation preventing aberrant off-target interactions with cellular microt...
ORGANISM(S): Homo sapiens (Human) 
2025-07-31 | PXD052722 | Pride
Lc-msms Axonemal dyneins Dnaaf Tmt Human multiciliated airway cells 
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