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ProteomicsStructural recognition and stabilization of tyrosine hydroxylase by the J-domain protein DNAJC12
Pathogenic variants of the J-domain protein DNAJC12, a co-chaperone of Hsp70, cause parkinsonism, which seems associated with a defective interaction of DNAJC12 with tyrosine hydroxylase (TH), the rate limiting enzyme in dopamine synthesis. Here, we report the characterization of TH:DNAJC12 complex ...
ORGANISM(S): Homo sapiens (Human) 
2025-01-27 | PXD056328 | Pride
Th Dnajc12 
ProteomicsStructural recognition and stabilization of tyrosine hydroxylase by the J-domain protein DNAJC12
Pathogenic variants of the J-domain protein DNAJC12, a co-chaperone of Hsp70, cause parkinsonism, which seems associated with a defective interaction of DNAJC12 with tyrosine hydroxylase (TH), the rate limiting enzyme in dopamine synthesis. Here, we report the characterization of TH:DNAJC12 complex ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-01 | PXD045185 | Pride
Tyrosine hydroxylase Hsp40 Dnajc12 Hsp70 Tyrosine hydroxylase deficiency 
GenomicsEffect of knockout of DNAJC12 on gene expression in SH-SY5Y cells [RNA-seq]
Effect of knockout of DNAJC12 on gene expression in SH-SY5Y cells [RNA-seq]
PRJNA1090452 | ENA
GenomicsEffect of knockout of DNAJC12 on gene expression in SH-SY5Y cells [ChIP-seq]
Effect of knockout of DNAJC12 on gene expression in SH-SY5Y cells [ChIP-seq]
PRJNA1092259 | ENA
GenomicsTranscriptomic profiling change of MDA-MB-231 cells overexpressing DNAJC12
Transcriptomic profiling change of MDA-MB-231 cells overexpressing DNAJC12
PRJNA789781 | ENA
TranscriptomicsEffect of knockout of DNAJC12 on gene expression in SH-SY5Y cells [RNA-seq]
We here reported DNAJC12 levels are negatively correlated with the prognosis of children with neuroblastoma and the knockout of DNAJC12 improves cell proliferation and invasion in neuroblastoma cells.DNAJC12 knockout results in increase of intracellular lactic acid and H4K5la modification level. DNA...
ORGANISM(S): Homo sapiens 
2024-03-31 | GSE262134 | GEO
GenomicsEffect of knockout of DNAJC12 on gene expression in SH-SY5Y cells [ChIP-seq]
We here reported DNAJC12 levels are negatively correlated with the prognosis of children with neuroblastoma and the knockout of DNAJC12 improves cell proliferation and invasion in neuroblastoma cells.DNAJC12 knockout results in increase of intracellular lactic acid and H4K5la modification level. DNA...
ORGANISM(S): Homo sapiens 
2024-03-31 | GSE262547 | GEO
UnknownHyperphenylalaninemia and serotonin deficiency in Dnajc12-deficient mice.
Not available
S-EPMC11655531 | biostudies-literature
UnknownDNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells.
Not available
S-EPMC7943744 | biostudies-literature
UnknownStructural recognition and stabilization of tyrosine hydroxylase by the J-domain protein DNAJC12.
Not available
S-EPMC11926245 | biostudies-literature
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