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MetabolomicsDIVA Metabolomics: Differentiating Vaccination Status Following Viral Challenge Using Metabolomic Profiles
This study employed metabolomic profiling technologies, to identify metabolites (small molecules) in blood which are found at different levels in vaccinated compared to non-vaccinated animals exposed to virus.
2018-07-13 | MTBLS456 | MetaboLights
TranscriptomicsAutism and increased paternal age related changes in global levels of gene expression regulation
A causal role of mutations in genes encoding for multiple general transcription factors in neurodevelopmental disorders including autism suggested that alterations at the global level of gene expression regulation might also relate to disease risk in sporadic cases of autism. This premise can be tes...
ORGANISM(S): Homo sapiens 
2011-10-08 | E-GEOD-25507 | biostudies-arrayexpress
UnknownNanodysferlins support membrane repair and binding to TRIM72/MG53 but do not localize to t-tubules or stabilize Ca<sup>2+</sup> signaling.
Not available
S-EPMC11109471 | biostudies-literature
ProteomicsThinking outside the CaaX-box: an unusual reversible prenylation on ALDH9A1
Protein lipidation is a post-translational modification that confers hydrophobicity on protein substrates to control their cellular localization, mediate protein trafficking, and regulate protein function. In particular, protein prenylation is a C-terminal modification on proteins bearing canonical ...
ORGANISM(S): Homo sapiens (Human) 
2023-11-06 | PXD036365 | Pride
Prenyaltion Lipidation Aldh9a1 Prenylomics Proteomics 
UnknownRandomized controlled trial of N-acetylcysteine therapy for RYR1-related myopathies.
Not available
S-EPMC7274912 | biostudies-literature
UnknownThe N-terminal region of DNMT3A engages the nucleosome surface to aid chromatin recruitment.
Not available
S-EPMC11624362 | biostudies-literature
UnknownClinical and Molecular Features of Long-term Response to Immune Checkpoint Inhibitors in Patients with Advanced Non-Small Cell Lung Cancer.
Not available
S-EPMC10618656 | biostudies-literature
ProteomicsThe NFIB/CARM1 Partnership is a Therapeutic Target for Small Cell Lung Cancer
This project identified NFI family members as CARM1 substrates. NFIB was previously reported to play a critical role in the development of small cell lung cancer. We provided evidence that the arginine methylation of NFIB is required for its oncogenic function in small cell lung cancer.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-11-19 | MSV000090746 | MassIVE
TranscriptomicsLiver Pharmacology and Xenobiotic Response Repertoire
A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology. We have used a ...
ORGANISM(S): Rattus norvegicus 
2008-03-28 | E-GEOD-8858 | biostudies-arrayexpress
TranscriptomicsInhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [Illumina HumanHT-12 gene expression array]
All-trans-retinoic acid (ATRA) has been successfully used in therapy of acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukemia (AML) but the response of non-APL AML cases to ATRA-based treatment has been poor. Here we show that, via epigenetic reprogramming,...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-34672 | biostudies-arrayexpress
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