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UnknownBi-allelic variants in DOHH, catalyzing the last step of hypusine biosynthesis, are associated with a neurodevelopmental disorder.
Not available
S-EPMC9388783 | biostudies-literature
UnknownRegulation of expression of deoxyhypusine hydroxylase (DOHH), the enzyme that catalyzes the activation of eIF5A, by miR-331-3p and miR-642-5p in prostate cancer cells.
Not available
S-EPMC3471734 | biostudies-literature
UnknownA novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation.
Not available
S-EPMC4107325 | biostudies-literature
ProteomicsEvaluation of N8-propargyl spermidine and spermine as substrates of deoxyhypusine synthase in the in vitro hypusination of eIF5A and RIPK1
eIF5A is a well-established protein substrate of deoxyhypusine synthase (DHS), which also requires spermidine as a small-molecule substrate. At the end of 2024, a publication claimed that RIPK1 is an additional DHS substrate and that N8-propargyl spermidine can also serve as a DHS substrate. To eval...
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD071577 | Pride
N8-propargyl spermidine Dhs Eif5a Chemical probe Hypusination Deoxyhypusine synthase Ripk1 
UnknownMolecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme.
Not available
S-EPMC1324997 | biostudies-literature
UnknownA unique modification of the eukaryotic initiation factor 5A shows the presence of the complete hypusine pathway in Leishmania donovani.
Not available
S-EPMC3306375 | biostudies-literature
UnknownDeoxyhypusine hydroxylase from Plasmodium vivax, the neglected human malaria parasite: molecular cloning, expression and specific inhibition by the 5-LOX inhibitor zileuton.
Not available
S-EPMC3591309 | biostudies-literature
UnknownDeoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected].
Not available
S-EPMC1868894 | biostudies-literature
UnknownIdentification of NRAS Downstream Genes with CRISPR Activation Screening.
Not available
S-EPMC9687188 | biostudies-literature
UnknownIron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase.
Not available
S-EPMC4050543 | biostudies-literature
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