Sort   by:  
 Page size 
ProteomicsAsparagine-linked glycosylation mediates glucose sensing for cell fate decision
Asparagine-linked glycosylation (N-glycosylation), a fundamental modification of proteins synthesized in the endoplasmic reticulum, is easily suppressed by glucose deprivation, but the role of this metabolic link has long remained unclear. We previously identified the activity of mannose metabolism,...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD066382 | Pride
Metabolism Cell fate decision Glucose deprivation N-glycosylation Unfolded protein response 
ProteomicsIdentification of Distinct N-Glycosylation Patterns on Extracellular Vesicles from Small-Cell and Non-Small-Cell Lung Cancer Cells
Asparagine-linked glycosylation (N-glycosylation) of proteins in the cancer secretome has gained increasing attention as a potential biomarker for cancer detection and diagnosis. Small extracellular vesicles (sEVs) constitute a large part of the cancer secretome, yet little is known about whether th...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD030865 | Pride
Human cancer small extracellular vesicles 
ProteomicsGlycometabolic regulation of the biogenesis of small extracellular vesicles
The biogenesis of small extracellular vesicles (sEVs) is regulated by multiple molecular machineries, generating considerably heterogeneous vesicle populations, i.e., exosomes and non-exosomal vesicles, with distinct cargo molecules. However, the role of carbohydrate metabolism in generating such ve...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-14 | PXD020670 | Pride
Exosome 
ProteomicsOvercoming off-targets: Assessing western blot signals for Bcnt/Cfdp1, a tentative component of the chromatin remodeling complex
The mammalian Bucentaur/Craniofacial developmental protein 1 (Bcnt/Cfdp1) is a tentative component of the Srcap (SNF2-Related CBP Activator Protein) chromatin remodeling complex, but little is known about its properties, partly because few antibodies are available to detect the endogenous protein.　W...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-03 | PXD019016 | Pride
Bcnt 
ProteomicsDisruption of endothelial glycocalyx after ischemic stroke onset: Activated scission activity of proHPSE by acrolein exposure
Infiltration of peripheral immune cells after blood-brain barrier (BBB) dysfunction causes severe inflammation after a stroke. Although the endothelial glycocalyx functions as a barrier to circulating cells, the relationship between stroke severity and glycocalyx dysfunction remains unclear. In this...
ORGANISM(S): Homo sapiens (Human) 
2020-11-16 | PXD021040 | Pride
Acrolein heparanase 
ProteomicsEpigenetic mechanisms to propagate histone acetylation by p300/CBP
Histone acetylation is important for the activation of gene transcription but little is known about its direct ‘read/write’ mechanisms. Here, we report cryo-electron microscopy structures in which a p300/CBP multidomain monomer recognizes histone H4 N-terminal tail (NT) acetylation (ac) in a nucleos...
ORGANISM(S): Homo sapiens (Human) 
2023-05-08 | PXD040835 | Pride
P300/cbp Histone Acetylation 
ProteomicsDevelopmental dynamics of the postsynaptic proteome to understand synaptic maturation and dysmaturation
The postsynaptic density (PSD) is a protein condensate composed of ~1,000 proteins beneath the postsynaptic membrane of excitatory synapses. The number, shape, and plasticity of synapses are altered during development. However, the dynamics of synaptic protein composition across development have not...
ORGANISM(S): Mus musculus (Mouse) Callithrix jacchus 
2024-01-17 | PXD048549 | Pride
Brain postsynaptic density mouse primate 
ProteomicsMetabolic clogging of mannose in human cancer cells triggers genome instability via dNTP loss
Mannose is an anti-cancer sugar that inhibits cell proliferation and enhances chemotherapy. How mannose exerts its anti-cancer activities, however, remains poorly understood. Here, using genetically engineered human cancer cells that permit the precise control of mannose metabolic flux, we demonstra...
ORGANISM(S): Homo sapiens (Human) 
2023-07-06 | PXD036449 | Pride
Mannose cancer 
ProteomicsPolyamines stimulate the protein synthesis of the initiation factor eIF5A2 participating in mRNA decoding distinct from eIF5A1
Polyamines are present in all living organisms, and their homeostasis is closely associated with human health and disease. Further, they are small aliphatic cations that exhibit multifunctional activities through interactions with acidic substances, thereby precluding our understanding of their mole...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD063151 | Pride
Polyamine Proteomics Eukaryotic initiation factor 5a (eif5a) Cell proliferation Spermidine 
ProteomicsCryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation
Members of the leucine-rich repeat-containing 8 (LRRC8) protein family, composed of the five LRRC8A-E isoforms, are pore-forming components of the volume-regulated anion channel (VRAC), which is activated by cell swelling and transports halide anions and small organic compounds. Despite the recent a...
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD018780 | Pride
Lrrc8d 
Sort   by:  
 Page size