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ProteomicsCharacterization of extracellular vesicles from Bothrops jararaca snake venom
Venoms are important evolutionary keys and innovation for several animal taxons., including snakes. Their use is specially related to feed, predation and defense. Snake venoms are composed mainly by free secreted proteins, about 98%, and stored in the lumen of the venom gland, where they are process...
ORGANISM(S): Bothrops jararaca (Jararaca) (Bothrops jajaraca) 
2023-03-10 | PXD037375 | Pride
Extracellular vesicles Snake venom 
MetabolomicsSarcopenic metabolomic profile reflected a sarcopenic phenotype associated with amino acid and essential fatty acid changes

INTRODUCTION: Although sarcopenia greatly affects health and quality of life in older people, its pathophysiological causes are not fully elucidated. To face this challenge, omics technologies can be used. The metabolome gives a vision of the interaction between the genome and t...

2021-09-29 | MTBLS2679 | MetaboLights
ProteomicsHuman brain Alzheimer's - Proteomic signatures of brain regions affected by tau pathology in early and late stages of Alzheimer's disease
Alzheimer’s disease (AD) is the most common neurodegenerative disorder being characterized by progressive impairment of memory and cognition, resulting in dementia. To investigate brain region vulnerability to AD and which pathways are altered in certain areas in AD, we performed proteomic profiling...
ORGANISM(S): Homo sapiens (Human) 
2019-07-01 | PXD010138 | Pride
Qe Human brain Alzheimer's disease 
UnknownExtracellular vesicles and vesicle-free secretome of the protozoa Acanthamoeba castellanii under homeostasis and nutritional stress and their damaging potential to host cells.
Not available
S-EPMC5955443 | biostudies-literature
UnknownShort-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men.
Not available
S-EPMC8619397 | biostudies-literature
UnknownTopological Dissection of Proteomic Changes Linked to the Limbic Stage of Alzheimer's Disease.
Not available
S-EPMC8546208 | biostudies-literature
UnknownShort-term effects of follicle-stimulating hormone on immune function, lipid, and vitamin metabolism in transiently castrated men.
Not available
S-EPMC11770401 | biostudies-literature
ProteomicsProteomic changes linked to the limbic stage of AD
Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia worldwide. In AD, neurodegeneration spreads throughout the brain cortex in a gradual and predictable pattern, causing progressive memory decline and cognitive impairment. Here, we conducted proteomic, acet...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD027173 | Pride
Neuroinflammation Proteomics Limbic stage Phosphoproteomics Alzheimer's disease 
ProteomicsProteomic Analysis of Whole Saliva in Chronic Periodontitis
Periodontitis is a chronic inflammatory disease resulting from a dysbiosis of the dental biofilm and a dysregulated host response in susceptible individuals. It is characterized by periodontal attachment destruction, bone resorption, and eventual tooth loss. Salivary biomarkers have been sought to p...
ORGANISM(S): Homo sapiens (Human) 
2020-05-20 | PXD015024 | Pride
Saliva  periodontitis  periodontal health  proteome  mass spectrometry 
ProteomicsTissue Proteome Signatures Associated with Five Grades of Prostate Cancer and Benign Prostatic Hyperplasia
Prostate cancer (PCa) remains a prevalent and deadly disease. The histology-based Gleason score (GS) of PCa tissue biopsy is the most accurate predictor of disease aggressiveness and an important measure to guide decision-making with respect to treatment strategies and patient management. However, i...
ORGANISM(S): Homo sapiens (Human) 
2019-10-09 | PXD013837 | Pride
Tissue Prostate cancer Proteome 
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