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UnknownExtension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.

Objective

Genome-wide association scans (GWASs) have identified novel diabetes-associated genes. We evaluated how these variants impact diabetes incidence, quantitative glycemic traits, and response to preventive interventions in 3,548 subjects at high risk of type 2 diabetes enrolled in the...
S-EPMC2518503 | biostudies-literature
UnknownGenetic modulation of lipid profiles following lifestyle modification or metformin treatment: the Diabetes Prevention Program.
Weight-loss interventions generally improve lipid profiles and reduce cardiovascular disease risk, but effects are variable and may depend on genetic factors. We performed a genetic association analysis of data from 2,993 participants in the Diabetes Prevention Program to test the hypotheses that a ...
S-EPMC3431328 | biostudies-literature
UnknownCirculating natriuretic peptide concentrations reflect changes in insulin sensitivity over time in the Diabetes Prevention Program.

Aims/hypothesis

We aimed to study the relationship between measures of adiposity, insulin sensitivity and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in the Diabetes Prevention Program (DPP).

Methods

The DPP is a completed clinical trial. Using stored samples from this resou...
S-EPMC4158711 | biostudies-literature
UnknownDiabetes autoantibodies do not predict progression to diabetes in adults: the Diabetes Prevention Program.

Aims

To determine if the presence of diabetes autoantibodies predicts the development of diabetes among participants in the Diabetes Prevention Program.

Methods

A total of 3050 participants were randomized into three treatment groups: intensive lifestyle intervention, metformin and pl...
S-EPMC4138247 | biostudies-literature
UnknownTCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program.

Aims

TCF7L2 variants have been associated with type 2 diabetes, body mass index (BMI), and deficits in proinsulin processing and insulin secretion. Here we sought to test whether these effects were apparent in high-risk individuals and modify treatment responses.

Methods

We examined t...
S-EPMC3144193 | biostudies-literature
UnknownEffects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program.
Common genetic variants have been recently associated with fasting glucose and insulin levels in white populations. Whether these associations replicate in pre-diabetes is not known. We extended these findings to the Diabetes Prevention Program, a clinical trial in which participants at high risk fo...
S-EPMC3439414 | biostudies-literature
UnknownConfirming glycemic status in the Diabetes Prevention Program: implications for diagnosing diabetes in high risk adults.

Aims

To examine the ability of fasting plasma glucose (FPG) and/or 2-h glucose to confirm diabetes and to determine the proportion of participants with HbA1c ≥6.5%.

Methods

Diabetes confirmation rates were calculated after a single elevated FPG and/or 2-h glucose on an oral glucose to...
S-EPMC3594066 | biostudies-literature
UnknownCommon variation at PPARGC1A/B and change in body composition and metabolic traits following preventive interventions: the Diabetes Prevention Program.

Aims/hypothesis

PPARGC1A and PPARGCB encode transcriptional coactivators that regulate numerous metabolic processes. We tested associations and treatment (i.e. metformin or lifestyle modification) interactions with metabolic traits in the Diabetes Prevention Program, a randomised controlled ...
S-EPMC4154629 | biostudies-literature
UnknownThe 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) score and diabetes risk in the Diabetes Prevention Program Outcomes Study (DPPOS).

Background

The 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) 3rd expert report highlights up-to-date Cancer Prevention Recommendations that may reduce burdens of many chronic diseases, including diabetes. This study examined if following a lifestyle that ...
S-EPMC9494851 | biostudies-literature
UnknownThe Impact of Physical Activity on the Prevention of Type 2 Diabetes: Evidence and Lessons Learned From the Diabetes Prevention Program, a Long-Standing Clinical Trial Incorporating Subjective and Objective Activity Measures.

Objective

Across the Diabetes Prevention Program (DPP) follow-up, cumulative diabetes incidence remained lower in the lifestyle compared with the placebo and metformin randomized groups and could not be explained by weight. Collection of self-reported physical activity (PA) (yearly) with cro...
S-EPMC7783946 | biostudies-literature
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