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GenomicsOSKM factors cooperatively engage chromatin to initiate reprogramming
Reprogramming cells from one fate to another, using transcription factors, generates cells for research and potential therapy, yet little is known about the initial engagement of reprogramming factors with the genome. We mapped the interactions between Oct4, Sox2, Klf4, and c-Myc (OSKM) and the hum...
ORGANISM(S): Homo sapiens 
2012-11-16 | E-GEOD-36570 | biostudies-arrayexpress
TranscriptomicsGene expression patterns in peripheral blood correlate with the extent of coronary artery disease
Gene expression profile in circulating leukocytes identifies patients with coronary artery disease Peter Sinnaeve, Mark Donahue, Peter Grass, Jacky Vonderscher, David Seo, Pascal Goldschmidt, Christopher Granger Department of Medicine, Duke University, Durham, NC, USA, Novartis Institute for Biome...
ORGANISM(S): Homo sapiens 
2008-10-31 | E-GEOD-12288 | biostudies-arrayexpress
GenomicsDynamics of Genomic H3K27me3 Domains and Role of EZH2 during Pancreatic Endocrine Specification
Endoderm cells undergo a sequence of fate choices to generate insulin-secreting M-NM-2 cells. Studies of chromatin transitions during this process have been limited to the pancreatic progenitor stage that can be reconstituted from stem cells in vitro, with a gap in understanding the induction of end...
ORGANISM(S): Mus musculus 
2014-07-28 | E-GEOD-56617 | biostudies-arrayexpress
UnknownPancreatic cancer patient survival correlates with DNA methylation of pancreas development genes.
Not available
S-EPMC4454596 | biostudies-literature
TranscriptomicsWhole Genome Sequencing Informs Therapeutic Selection for Pancreatic Cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole genome sequencing and CNV analysis of 100 pancreatic ductal adenocarcinomas. Chromosomal rearrangements leading to gene disruption were frequent, affecting genes known to be important in pa...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-61502 | biostudies-arrayexpress
UnknownThe effects of exercise on cardiovascular biomarkers in patients with chronic heart failure.
Not available
S-EPMC3899586 | biostudies-literature
TranscriptomicsGene expression changes in the intestinal crypts of mice with loss of imprinting
To identify genes differentially expressed in the intestinal crypts between LOI(+) and LOI(-) mice, we performed microarray experiments using RNA extracted from laser capture microdissection, by microdissecting an average of 8,000 crypts from each of 3 LOI(+) and 3 LOI(-) mice. Keywords: genetic mo...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-8583 | biostudies-arrayexpress
UnknownLysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming.
Not available
S-EPMC6697184 | biostudies-literature
TranscriptomicsTranscription profiling of human mesenchymal stem cell derived stromal and adipocyte cells treated with insulin.
There are an estimated 21million diabetics in the United States and 150 million diabetics worldwide. The World Health Organization anticipates that these numbers will double in the next 20 years. Metabolic syndrome is a well recognized set of symptoms that increases a patient’s risk of developing d...
ORGANISM(S): Homo sapiens 
2010-11-30 | E-GEOD-24422 | biostudies-arrayexpress
ProteomicsEffects of the chlorophyll derivative 132-hydroxypheophytine a on zebrafish metabolomics
Zebrafish larvae were exposed from 3 DPF to 5 DPF to the chlorophyll derivative 13-2-hydroxypheophytine a. Metabolites were extracted with some modification of the protocol published by Lin et al 2019 (10.1016/j.bbrc.2019.04.003.). 3 experimental groups: DMSO 0.1% (solvent control) and hpa at 7.5 ug...
ORGANISM(S): Danio Rerio (ncbitaxon:7955) 
2023-06-16 | MSV000092187 | MassIVE
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