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MetabolomicsMetabolomic and Metataxonomic Fingerprinting of Human Milk Suggests Compositional Stability over a Natural Term of Breastfeeding to 24 Months
Sparse data exist regarding the normal range of composition of maternal milk beyond the first postnatal weeks. This single timepoint, observational study in collaboration with the 'Parenting Science Gang' citizen science group evaluated the metabolite and bacterial composition of human milk from 62 ...
2022-02-11 | MTBLS1370 | MetaboLights
MetabolomicsUntargeted metabolomic analysis of human milk from healthy mothers reveals drivers of metabolite variability.
Understanding the human milk metabolome can help inform infant nutrition and health. Untargeted metabolomics was used to study breast milk from 31 healthy participants to assess the shared metabolites in milk from participants with various backgrounds and understand how different demographic, health...
2024-10-04 | MTBLS2419 | MetaboLights
MetabolomicsModulating the developing gut microbiota with 2’-fucosyllactose and pooled human milk oligosaccharides

Synthetic human milk oligosaccharide (HMO) structures are used to supplement infant formula despite limited understanding of their impact on the developing gut microbiota. Here, we assess the impact of 2-fucosyllactose (2’FL) and pooled (p)HMOs on the composition and activity of cultured microbia...

2024-09-03 | MTBLS9853 | MetaboLights
MetabolomicsHuman milk as infantile Super Food - the effect of dietary choices and supplementation on the shift of lipidomic profile during different stages of lactation
The objective of this project was to establish an advanced analytical method leveraging high-resolution mass spectrometry LC-HRMS to comprehensively profile the human milk lipidome. Mass spectrometry resolves and quantifies compounds based on a fundamental physical metric: the mass-to-charge ratio. ...
2026-09-22 | MTBLS15678 | MetaboLights
ProteomicsEffects of non-thermal methods (High-Pressure Processing, UV-C irradiation and thermoultrasonication) on donor human milk safety and functionality
This study was conducted in order to evaluate the effects of high-pressure processing, UV-C irradiation and thermo-ultrasonication on donor human milk safety and quality. The results of these methods were then compared with holder pasteurization, which is the current recommended treatment for donor ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-11 | PXD031216 | Pride
Holder pasteurization Bacteria inactivation Hpp Antimicrobial proteins Donor human milk Uv-c Tus 
ProteomicsAllergen Shedding in Human Milk from Mothers of Preterm Infants: Proteomic and Peptidomic Feasibility and Pilot Analysis
There is little information regarding the allergen content of milk feeds in the preterm population. Previous studies have evaluated specific proteins/peptides via ELISA, but no studies have performed a broad analysis of the allergenic peptide content and protease activity of milk feeds in this popul...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2024-01-26 | PXD033473 | Pride
Human Allergen Native paptides Milk 
MetabolomicsMulti-omics and intervention analyses reveal a hindgut microbiota–secondary bile acid–mammary axis linked to milk yield in dairy cows
Background In large scale dairy farming systems, maintaining stable milk yield post-lactation peak is crucial for dairy farms’ economic benefits. While sufficient evidence shows the microbiota profoundly impacts host production efficiency, the specific mechanisms by which hindgut microbiota support ...
2026-05-22 | MTBLS14549 | MetaboLights
ProteomicsEndegenous human milk peptides
Variations in endogenous peptide profiles, functionality, and the enzymes responsible for the formation of these peptides in human milk are understudied. Additionally, there is a lack of knowledge regarding peptides in donor human milk, which is used to feed preterm infants when mother’s own milk is...
ORGANISM(S): Homo sapiens (Human) 
2022-02-24 | PXD007967 | Pride
Human milk Peptides Endegenous 
ProteomicsPersonalized Human Milk Profiling
Human milk is the truest form of personalized nutrition, supporting dynamic needs of the infant with important nutritional and bioactive constituents that change throughout lactation. Additionally, human milk is individual specific and is unique for each mother-infant dyad. Proteins and endogenous p...
ORGANISM(S): Homo sapiens (Human) 
2021-02-09 | PXD014917 | Pride
Human milk Immunity Endogenous peptides Personalized nutrition Proteins 
ProteomicsMilk glycopeptide across lactation
Protein N-glycosylation is an essential post-translational modification (PTM) frequently occurring on human milk proteins. These PTMs assist in protecting the infant's health and function amongst others as competitive inhibitors of pathogen binding and immunomodulators. Due to the individual unique...
ORGANISM(S): Homo Sapiens 
2020-11-07 | PXD022415 | panorama
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