Sort   by:  
 Page size 
GenomicsChIP-seq analysis of Foxa2 binding sites in midbrain dopaminergic progenitors
Embryonic stem (ES) cells were differentiated in culture to midbrain dopaminergic (mDA) progenitors and subjected to ChIP-seq analysis to resolve genome-wide binding sites of forkhead box protein A2 (Foxa2). Foxa2 was found to directly regulate multiple lineage pathways to specify midbrain dopaminer...
ORGANISM(S): Mus musculus 
2012-07-01 | E-MTAB-1137 | biostudies-arrayexpress
TranscriptomicsEH004: Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/b-catenin signaling activator Rspo2
Recent developments in molecular programming of mesodiencephalic dopaminergic (mdDA) neurons have led to the identification of many transcription factors playing a role in mdDA specification. LIM homeodomain transcription factor Lmx1a is essential for chick mdDA development, and for the efficient di...
ORGANISM(S): Mus musculus 
2013-12-13 | E-GEOD-45831 | biostudies-arrayexpress
GenomicsChIP-seq analysis of Foxa2 binding sites in midbrain dopaminergic progenitors
ChIP-seq analysis of Foxa2 binding sites in midbrain dopaminergic progenitors
PRJEB3033 | ENA
ProteomicsEnrichment, proteome analysis and transplantation of human embryonic stem cell derived dopaminergic progenitors expressing LMX1a
Despite the progress in safety and efficacy of cell therapy with pluripotent stem cells (PSCs), the presence of residual undifferentiated stem cells or proliferating neural progenitor cells (NPCs) with rostral identity has remained a major challenge. Here we reported the generation of an LMX1A knock...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD007837 | Pride
Parkinson disease Pluripotent stem cells Quantitative proteomics Hesc 
ProteomicsIdentifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells
Ventral midbrain (VM) dopaminergic progenitor cells derived from human pluripotent stem cells have the potential to replace endogenously lost dopamine neurons and are currently in preclinical and clinical development for treatment of Parkinson’s Disease (PD). However, one main challenge in the quali...
ORGANISM(S): Homo sapiens (Human) 
2023-12-13 | PXD039510 | Pride
Parkinson’s disease Cell replacement therapy Mass spectrometry Dopaminergic progenitors Biomarkers 
GenomicsDirect reprogramming of human fibroblasts to expandable induced dopaminergic neuronal progenitors for Parkinson’s disease therapy [Array]
Direct reprogramming of human fibroblasts to expandable induced dopaminergic neuronal progenitors for Parkinson’s disease therapy [Array]
PRJNA661193 | ENA
GenomicsDirect reprogramming of human fibroblasts to expandable induced dopaminergic neuronal progenitors for Parkinson’s disease therapy [ChIP-seq]
Direct reprogramming of human fibroblasts to expandable induced dopaminergic neuronal progenitors for Parkinson’s disease therapy [ChIP-seq]
PRJNA661026 | ENA
TranscriptomicsIsolation of human iPSC-derived dopaminergic progenitors by cell sorting
Human induced pluripotent stem cells (iPSCs) can provide a promising source of midbrain dopaminergic (DA) neurons for cell replacement therapy for Parkinson’s disease. However, iPSC-derived donor cells may inevitably contain tumorigenic or inappropriate cells. Purification of neural progenitor cells...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-51214 | biostudies-arrayexpress
UnknownSingle-cell transcriptomics reveals the cell fate transitions of human dopaminergic progenitors derived from hESCs.
Not available
S-EPMC9375405 | biostudies-literature
GenomicsPatterning effects of FGF17 and cAMP on generation of dopaminergic progenitors for cell replacement therapy in Parkinson’s disease. [scRNA-Seq]
Patterning effects of FGF17 and cAMP on generation of dopaminergic progenitors for cell replacement therapy in Parkinson’s disease. [scRNA-Seq]
PRJNA1108259 | ENA
Sort   by:  
 Page size