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TranscriptomicsExpression data from NOD and C57BL/6 mouse pancreas CD8α- Dendritic Cells (DCs) under steady-state and after in-vitro LPS stimulation
Abstract Two major dendritic cell (DC) subsets have been described in the islets of mice: The immunogenic CD8α-CD11b+ DCs and the tolerogenic CD8α+CD103+ DCs. We have recently reported on reduced numbers of the minor population of tolerogenic CD8α+CD103+ DCs in the pancreas of 5 week old pre-dia...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-45028 | biostudies-arrayexpress
TranscriptomicsMethionine Sulfoximine Resistance in Mycobacterium tuberculosis Is Due to a Single Nucleotide Deletion Resulting in Increased Expression of the Major Glutamine Synthetase, GlnA1.
We investigated the effect of methionine sulfoximine (MetSox), a potent inhibitor of glutamine synthetase, on Mycobacterium tuberculosis. M. tuberculosis encodes four glutamine synthetases, of which MetSox targets the type I enzyme encoded by glnA1. Trancriptional profiling revealed that glutamate s...
ORGANISM(S): Mycobacterium tuberculosis 
2011-09-06 | E-BUGS-112 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of defined Mycobacterium tuberculosis populations using RNA amplification strategies
Background The amplification of bacterial RNA is required if complex host-pathogen interactions are to be studied where the recovery of bacterial RNA is limited. Here, using a whole genome Mycobacterium tuberculosis microarray to measure cross-genome representation of amplified mRNA populations, we ...
ORGANISM(S): Mycobacterium tuberculosis 
2008-03-12 | E-BUGS-42 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse dendritic cells treated with Lactobacillus acidophilus to investigate the induction of virus immune defense genes
Lactobacilli are probiotics that, among other health promoting effects, have been ascribed immunostimulating and virus preventive properties. Certain lactobacilli species have been shown to possess strong IL-12 inducing properties. As IL-12 production depends on the up-regulation of type I interfero...
ORGANISM(S): Mus musculus 
2009-10-20 | E-GEOD-18460 | biostudies-arrayexpress
TranscriptomicsExpression data in splenic DC subsets in wild type and Xbp1 deficient mice
Xbp1 is a major transcription factor in the unfolded protein response. To uncover its function in DCs we generated a conditional KO for Xbp1 in dendritic cells. We here compare the expression of mRNAs in two different splenic DC subpopulations, CD8a and CD11b DCs in both WT and KO mice. Reference: I...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-52857 | biostudies-arrayexpress
TranscriptomicsRNA-seq profiling of Medulloblastoma
An observational experiment to RNA-seq profile 331 primary tumours from patients diagnosed with Medulloblastoma.
ORGANISM(S): Homo sapiens 
2022-09-01 | E-MTAB-10767 | biostudies-arrayexpress
TranscriptomicsUV-irradiation of skin enhances glycolytic flux in bone marrow-differentiated dendritic cells
Following UV irradiation of skin, dendritic cells (DCs) differentiating from the bone marrow (BM) of mice have a reduced ability to prime new immune responses; their reduced immunogenicity is maintained for at least 16 weeks in UV-chimeric mice. We hypothesized that different metabolic states underp...
ORGANISM(S): Mus musculus 
2015-10-30 | E-GEOD-74468 | biostudies-arrayexpress
TranscriptomicsExpression profiling following SMARCB1 re-expression in MRT cell lines time course over 14 days
MRT cell lines KD, SWOH, LM, DEV and G401 were expression profiled following SMARCB1 re-expression using a lentivirus. Samples were taken at Day 0,1,3,7 and 14 and compared to empty vector control experiments.
ORGANISM(S): Homo sapiens 
2024-12-31 | E-MTAB-6674 | biostudies-arrayexpress
UnknownGenetic modifiers of liver disease in cystic fibrosis.
Not available
S-EPMC3711243 | biostudies-literature
UnknownNeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases.
Not available
S-EPMC4317375 | biostudies-literature
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